Background: A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their ...

The Guilt-by-Association (GBA) principle, according to which genes with similar expression profiles are functionally associated, is widely applied for functional analyses using large heterogeneous collections of transcriptomics ...

Graphs are common representation tools to organize information from heterogeneous sources. They have been applied in various domains such as the scientific, engineering, political, and business sectors. The large volume ...

For a given query raised by a specific user, the Query Suggestion technique aims to recommend relevant queries which potentially suit the information needs of that user. Due to the complexity of the Web structure and the ...

An important problem in computational biology is the identification of candidate genes which can be considered as representative of the different cellular processes taking place in the cell as it evolves through time. ...

Abstract - By imitating the way that heat flows in a medium with a geometric structure, we propose two novel classification algorithms, Non-propagating Heat Diffusion Classifier (NHDC) and Propagating Heat Diffusion ...

The incomplete information about the Web structure causes inaccurate results of various ranking algorithms. In this paper, we propose a solution to this problem by formulating a new framework called, Predictive Random Graph ...

Phylogenetic models of the evolution of protein-coding sequences can provide insights into the selection pressures that have shaped them. In the application of these models synonymous nucleotide substitutions, which do not ...

Data sparsity, scalability and prediction quality have been recognized as the three most crucial challenges that every collaborative filtering algorithm or recommender system confronts. Many existing approaches to recommender ...