Browsing by Author "Woods, Robert J"
Now showing items 1-7 of 7
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Computational design of glycomimetic inhibitors of Influenza A Adhesion
Smith, Hannah Mary Kate (2015-02-16)Many pathogens, such as avian influenza, Helicobacter pylori and Streptococcus pneumoniae, employ cell-surface glycans which terminate in Neu5AcAlpha(2-3)Gal as their adhesion partner.[1] As a result, a glycomimetic ... -
Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan–protein complexes
Woods, Robert J; Tessier, Matthew B (Elsevier BV, 2010-10-01)Modern computational methods offer the tools to provide insight into the structural and dynamic properties of carbohydrate-protein complexes beyond that provided by experimental structural biology Dynamic properties such ... -
Defining the structural origin of the substrate sequence independence of o-glcnacase using a combination of molecular docking and dynamics simulation
Martin, Joanne C; Fadda, Elisa; Ito, Keigo; Woods, Robert J (Oxford University Press (OUP), 2013-10-16)Protein glycosylation with O-linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification of serine/threonine residues in nucleocytoplasmic proteins. O-GlcNAc has been shown to play a role in many different ... -
Expression, purification and characterization of carbohydrate-binding proteins
Murphy, Valerie (2014-05-29)Glycans play important roles in many biological interactions. They are involved in cell-cell interactions, function as a point of entry for viral infections and facilitate the adhesion of microbes in the body. Glycans of ... -
N- and O- linked Glycosylation, Developing Mass Spectrometric Strategies for the Characterisation of Glyco-epitopes
Kenny, Diarmuid T (2012-12-10)The overall goal of this thesis was to adopt a liquid chromatography-mass spectrometry (LC-MS) platform for glycomic analysis of glycoproteins. In particular we were interested in characterizing complex glycomic samples ... -
Recent advances in employing molecular modelling to determine the specificity of glycan-binding proteins
Grant, Oliver C; Woods, Robert J (Elsevier BV, 2014-10-01)Impressive improvements in docking performance can be achieved by applying energy bonuses to poses in which glycan hydroxyl groups occupy positions otherwise preferred by bound waters. In addition, inclusion of glycosidic ... -
Structure and binding analysis of polyporus squamosus lectin in complex with the neu5acα2-6galβ1-4glcnac human-type influenza receptor
Kadirvelraj, Renuka; Grant, Oliver C; Goldstein, Irwin J; Winter, Harry C; Tateno, Hiroaki; Fadda, Elisa; Woods, Robert J (Oxford University Press (OUP), 2011-03-24)Glycan chains that terminate in sialic acid (Neu5Ac) are frequently the receptors targeted by pathogens for initial adhesion. Carbohydrate-binding proteins (lectins) with specificity for Neu5Ac are particularly useful in ...