Browsing by Author "Tussiwand, Roxane"
Now showing items 1-3 of 3
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A stromal cell free culture system generates mouse pro-t cells that can reconstitute t-cell compartments in vivo
Gehre, Nadine; Nusser, Anja; von Muenchow, Lilly; Tussiwand, Roxane; Engdahl, Corinne; Capoferri, Giuseppina; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (Wiley-Blackwell, 2014-12-16)T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture ... -
The pretcr-dependent dn3 to dp transition requires notch signaling, is improved by cxcl12 signaling and is inhibited by il-7 signaling
Tussiwand, Roxane; Engdahl, Corinne; Gehre, Nadine; Bosco, Nabil; Ceredig, Rod; Rolink, Antonius G. (Wiley-Blackwell, 2011-10-04)The requirement for Notch signaling during T-cell development has been extensively studied. Nevertheless, the developmental stage at which it is required and whether additional signaling pathways are needed are still poorly ... -
Tolerance checkpoints in b-cell development: johnny b good
Tussiwand, Roxane; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (Wiley-Blackwell, 2009-08-27)B-cell development up to the immature B-cell stage takes place in the bone marrow, while final maturation into mature B cells occurs in the spleen. During differentiation, the precursor and immature B cells have to pass ...