Browsing by Author "Szegezdi, E"
Now showing items 1-5 of 5
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Differential activation of jnk1 isoforms by trail receptors modulate apoptosis of colon cancer cell lines
Mahalingam, D; Keane, M; Pirianov, G; Mehmet, H; Samali, A; Szegezdi, E (Springer Nature, 2009-04-07)Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5). TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor ... -
Early growth response-1 is a regulator of dr5-induced apoptosis in colon cancer cells
Mahalingam, D; Natoni, A; Keane, M; Samali, A; Szegezdi, E (Springer Nature, 2010-01-19) -
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing trail variants
Reis, C R; van der Sloot, A M; Natoni, A; Szegezdi, E; Setroikromo, R; Meijer, M; Sjollema, K; Stricher, F; Cool, R H; Samali, A; Serrano, L; Quax, W J (Springer Nature, 2010-10-01)The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered ... -
Resistance to trail in non-transformed cells is due to multiple redundant pathways
van Dijk, M; Halpin-McCormick, A; Sessler, T; Samali, A; Szegezdi, E (Springer Nature, 2013-07-01)Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed cells. A large number of chemotherapeutics ... -
Trail sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and akt
Szegezdi, E; Cahill, S; Meyer, M; O'Dwyer, M; Samali, A (Springer Nature, 2006-01-24)The majority of leukaemic cells are resistant to apoptosis induced by tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). Here, we show that sublethal concentrations of arsenic trioxide (ATO) specifically ...