Browsing by Author "Ryan, Aideen E"
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Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
Lohan, Paul; Coleman, Cynthia M; Murphy, J; Griffin, Matthew D; Ritter, Thomas; Ryan, Aideen E (Springer Nature, 2014-01-01)Mesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs have potent ... -
Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation
Ryan, Aideen E; Lohan, Paul; O'Flynn, Lisa; Treacy, Oliver; Chen, Xizhe; Coleman, Cynthia; Shaw, Georgina; Murphy, Mary; Barry, Frank; Griffin, Matthew D; Ritter, Thomas (Elsevier BV, 2014-03-01)Allogeneic mesenchymal stem cells (allo-MSCs) have potent regenerative and immunosuppressive potential and are being investigated as a therapy for osteoarthritis; however, little is known about the immunological changes ... -
Donor bone marrow–derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu
O'Flynn, Lisa; Treacy, Oliver; Ryan, Aideen E; Morcos, Maurice; Cregg, Marese; Gerlach, Jared; Joshi, Lokesh; Nosov, Mikhail; Ritter, Thomas (Elsevier BV, 2013-11-01)Investigations into cell therapies for application in organ transplantation have grown. Here, we describe the ex vivo generation of donor bone marrow-derived dendritic cells (BMDCs) and glucocorticoid-treated BMDCs with ... -
Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
Rani, Sweta; Ryan, Aideen E; Griffin, Matthew D; Ritter, Thomas (Elsevier BV, 2015-05-01)Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the current interest in therapeutic ... -
Pullulan: a new cytoadhesive for cell-mediated cartilage repair
Bulman, Sarah E; Coleman, Cynthia M; Murphy, J Mary; Medcalf, Nicholas; Ryan, Aideen E; Barry, Frank (Springer Nature, 2015-03-19)Introduction: Local delivery of mesenchymal stem cells (MSCs) to the acutely injured or osteoarthritic joint retards cartilage destruction. However, in the absence of assistive materials the efficiency of engraftment of ... -
Vil-10-overexpressing human mscs modulate naïve and activated t lymphocytes following induction of collagenase-induced osteoarthritis
Farrell, Eric; Fahy, Niamh; Ryan, Aideen E; Flatharta, Cathal O; O’Flynn, Lisa; Ritter, Thomas; Murphy, J Mary (Springer Nature, 2016-05-18)Background: Recent efforts in osteoarthritis (OA) research have highlighted synovial inflammation and involvement of immune cells in disease onset and progression. We sought to establish the in-vivo immune response in ...