Browsing by Author "Ryan, Aideen"
Now showing items 1-6 of 6
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Autophagosomal iκbα degradation plays a role in the long term control of tumor necrosis factor-α-induced nuclear factor-κb (nf-κb) activity
Colleran, Amy; Ryan, Aideen; O'Gorman, Angela; Mureau, Coralie; Liptrot, Catherine; Dockery, Peter; Fearnhead, Howard; Egan, Laurence J. (American Society for Biochemistry & Molecular Biology (ASBMB), 2011-03-31)Transcription factor NF-kappa B is persistently activated in many chronic inflammatory diseases and cancers. The short term regulation of NF-kappa B is well understood, but little is known about the mechanisms of its long ... -
Cellular interactions in the tumour microenvironment during inflammation-associated carcinogenesis
O'Malley, Grace (2017-11-30)The colon tumour microenvironment is highly stromal in composition and a greater stromal cell density correlates with a poor prognosis for patients. The majority of these stromal cells are of mesenchymal origin (MSCs) and ... -
Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury
Curley, Gerard F.; Ansari, Bilal; Hayes, Mairead; Devaney, James; Masterson, Claire; Ryan, Aideen; Barry, Frank; O’Brien, Timothy; Toole, Daniel O’; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2013-04-01)Background: Mesenchymal stromal cells (MSCs) have been demonstrated to attenuate acute lung injury when delivered by intravenous or intratracheal routes. The authors aimed to determine the efficacy of and mechanism of ... -
Enhancing the immunomodulatory efficacy of allogeneic mesenchymal stromal cells through pro-inflammatory cytokine licensing
Canning, Aoife (NUI Galway, 2024-04-17)The therapeutic efficacy and immunomodulatory potential of mesenchymal stromal cells (MSCs) is well established. MSCs have been employed as cellular therapies to treat various inflammatory-based conditions. MSC potency can ... -
Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
Curley, Gerard F; Hayes, Mairead; Ansari, Bilal; Shaw, Georgina; Ryan, Aideen; Barry, Frank; O'Brien, Timothy; O'Toole, Daniel; Laffey, John G (BMJ, 2011-11-21)Background Bone-marrow derived mesenchymal stem cells (MSCs) reduce the severity of evolving acute lung injury (ALI), but their ability to repair the injured lung is not clear. A study was undertaken to determine the ... -
Targeting the ep1 receptor reduces fas ligand expression and increases the antitumor immune response in anin vivomodel of colon cancer
O'Callaghan, Grace; Ryan, Aideen; Neary, Peter; O'Mahony, Caitlin; Shanahan, Fergus; Houston, Aileen (Wiley-Blackwell, 2013-03-04)Despite studies demonstrating that inhibition of cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) has significant chemotherapeutic benefits in vitro and in vivo, inhibition of COX enzymes is associated with serious ...