Browsing by Author "Roy, René"
Now showing items 1-2 of 2
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Multivalent carbohydrate-lectin interactions: how synthetic chemistry enables insights into nanometric recognition
Roy, René; Murphy, Paul; Gabius, Hans-Joachim (MDPI AG, 2016-05-13)Glycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. ... -
Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
Roy, René; Cao, Yihong; Kaltner, Herbert; Kottari, Naresh; Shiao, Tze Chieh; Belkhadem, Karima; André, Sabine; Manning, Joachim C.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2016-06-24)A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ...