Now showing items 1-2 of 2

    • E-selectin ligands recognised by heca452 induce drug resistance in myeloma, which is overcome by the e-selectin antagonist, gmi-1271 

      Natoni, A; Smith, T A G; Keane, N; McEllistrim, C; Connolly, C; Jha, A; Andrulis, M; Ellert, E; Raab, M S; Glavey, S V; Kirkham-McCarthy, L; Kumar, S K; Locatelli-Hoops, S C; Oliva, I; Fogler, W E; Magnani, J L; O'Dwyer, M E (Springer Nature, 2017-04-25)
      Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ST3Gal-6, an enzyme ...
    • Targeting the pim kinases in multiple myeloma 

      Keane, N A; Reidy, M; Natoni, A; Raab, M S; O'Dwyer, M (Springer Nature, 2015-07-17)
      Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine/threonine kinases with increased expression ...