Browsing by Author "Prosser, Suzanna L."

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    • Centrin2 regulates cp110 removal in primary cilium formation 

      Prosser, Suzanna L.; Morrison, Ciaran G. (Rockefeller University Press, 2015-03-09)
      Primary cilia are antenna-like sensory microtubule structures that extend from basal bodies, plasma membrane-docked mother centrioles. Cellular quiescence potentiates ciliogenesis, but the regulation of basal body formation ...

    • Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis 

      Prosser, Suzanna L.; Sahota, Navdeep K.; Pelletier, Laurence; Morrison, Ciaran G.; Fry, Andrew M. (Rockefeller University Press, 2015-05-11)
      Nek5 is a poorly characterized member of the NIMA-related kinase family, other members of which play roles in cell cycle progression and primary cilia function. Here, we show that Nek5, similar to Nek2, localizes to the ...

    • Oscillation of apc/c activity during cell cycle arrest promotes centrosome amplification 

      Prosser, Suzanna L.; Samant, Mugdha D.; Baxter, Joanne E.; Morrison, Ciaran G.; Fry, Andrew M. (The Company of Biologists, 2012-09-06)
      Centrosome duplication is licensed by the disengagement, or 'uncoupling', of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature ...