Browsing by Author "O’Gara, James P."
Now showing items 1-3 of 3
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5-hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due tostaphylococcus aureus
Zapotoczna, Marta; Murray, Ewan J.; Hogan, Siobhan; O’Gara, James P.; Chhabra, Siri R.; Chan, Weng C.; O’Neill, Eoghan; Williams, Paul (Oxford University Press (OUP), 2016-12-20)Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential ... -
Glycomics microarrays reveal differential in situ presentation of the biofilm polysaccharide Poly-N-acetylglucosamine on Acinetobacter baumannii and Staphylococcus aureus cell surfaces
Flannery, Andrea; Le Berre, Marie; Pier, Gerald B.; O’Gara, James P.; Kilcoyne, Michelle (MDPI, 2020-04-02)The biofilm component poly-N-acetylglucosamine (PNAG) is an important virulence determinant in medical-device-related infections caused by ESKAPE group pathogens including Gram-positive Staphylococcus aureus and Gram-negative ... -
The possible role of staphylococcus epidermidis lpxtg surface protein sesc in biofilm formation
Khodaparast, Laleh; Khodaparast, Ladan; Shahrooei, Mohammad; Stijlemans, Benoit; Merckx, Rita; Baatsen, Pieter; O’Gara, James P.; Waters, Elaine; Van Mellaert, Lieve; Van Eldere, Johan (Public Library of Science (PLoS), 2016-01-22)Staphylococcus epidermidis is the most common cause of device-associated infections. It has been shown that active and passive immunization in an animal model against protein SesC significantly reduces S. epidermidis ...