Browsing by Author "Gaboriau, David"
Now showing items 1-5 of 5
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Centriole splitting caused by loss of the centrosomal linker protein c-nap1 reduces centriolar satellite density and impedes centrosome amplification
Flanagan, Anne-Marie; Stavenschi, Elena; Basavaraju, Shivakumar; Gaboriau, David; Hoey, David A.; Morrison, Ciaran G. (American Society for Cell Biology (ASCB), 2017-01-18)Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker ... -
Centrobin controls primary ciliogenesis in vertebrates
Ogungbenro, Yetunde Adesanya; Tena, Teresa Casar; Gaboriau, David; Lalor, Pierce; Dockery, Peter; Philipp, Melanie; Morrison, Ciaran G. (Rockefeller University Press, 2018-02-13)The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNT ROB in hTERT-RPE1 cells and observed an increased ... -
Cep164-null cells generated by genome editing show a ciliation defect with intact dna repair capacity
Daly, Owen M.; Gaboriau, David; Karakaya, Kadin; King, Sinéad; Dantas, Tiago J.; Lalor, Pierce; Dockery, Peter; Krämer, Alwin; Morrison, Ciaran G. (The Company of Biologists, 2016-03-10)Primary cilia are microtubule structures that extend from the distal end of the mature, mother centriole. CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium ... -
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint
Maffini, Stefano; Rainey, Michael D.; Kaczmarczyk, Agnieszka; O'Connor, Aisling; Gaboriau, David; Musacchio, Andrea; Santocanale, Corrado (Company of Biologists, 2016)During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ... -
The deubiquitinase usp9x maintains dna replication fork stability and dna damage checkpoint responses by regulating claspin during s-phase
McGarry, Edel; Gaboriau, David; Rainey, Michael D.; Restuccia, Umberto; Bachi, Angela; Santocanale, Corrado (American Association for Cancer Research (AACR), 2016-02-26)