Browsing by Author "Friel, Ruairi"
Now showing items 1-3 of 3
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Antibacterial potential of an antimicrobial agent inspired by peroxidase-catalyzed systems
Tonoyan, Lilit; Fleming, Gerard T. A.; Mc Cay, Paul H.; Friel, Ruairi; O'Flaherty, Vincent (Frontiers Media, 2017-05-02)Antibiotic resistance is an increasingly serious threat to global health. Consequently, the development of non-antibiotic based therapies and disinfectants, which avoid induction of resistance, or cross-resistance, is of ... -
Continuous culture of Escherichia coli, under selective pressure by a novel antimicrobial complex, does not result in development of resistance
Tonoyan, Lilit; Fleming, Gerard T. A.; Friel, Ruairi; O’Flaherty, Vincent (Nature Research, 2019-02-20)We attempted to generate de novo resistance to a newly described biocidal complex, ITC (iodo-thiocyanate complex), and to levofloxacin (LVX) in Escherichia coli ATCC 25922, by means of selective chemostat culture. We ... -
In vitro comparative cytotoxicity study of a novel biocidal iodo-thiocyanate complex
Tonoyan, Lilit; Boyd, Aoife; Fleming, Gerard T.A.; Friel, Ruairi; Gately, Carol M.; Mc Cay, Paul H.; O'Flaherty, Vincent (Elsevier, 2018-04-03)Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate ...