Browsing by Author "Duffy, D. J."
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Induced stem cell neoplasia in a cnidarian by ectopic expression of a pou domain transcription factor
Millane, R. C.; Kanska, J.; Duffy, D. J.; Seoighe, C.; Cunningham, S.; Plickert, G.; Frank, U. (The Company of Biologists, 2011-05-24)The evolutionary origin of stem cell pluripotency is an unresolved question. In mammals, pluripotency is limited to early embryos and is induced and maintained by a small number of key transcription factors, of which the ... -
Wnt signaling promotes oral but suppresses aboral structures in hydractinia metamorphosis and regeneration
Duffy, D. J.; Plickert, G.; Kuenzel, T.; Tilmann, W.; Frank, U. (The Company of Biologists, 2010-08-04)We studied the role of Wnt signaling in axis formation during metamorphosis and regeneration in the cnidarian Hydractinia. Activation of Wnt downstream events during metamorphosis resulted in a complete oralization of the ...