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Now showing items 8490-8509 of 14593
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Microplastics in corals: An emergent threat
(Elsevier, 2020-11-01)This article seeks to present a summary of knowledge and thus improve awareness of microplastic impacts on corals. Recent research suggests that microplastics have a variety of species-specific impacts. Among them, a reduced ... -
Microplastics in sewage sludge: effects of treatment
(American Chemical Society, 2016-12-12)Waste Water Treatment Plants (WWTPs) are receptors for the cumulative loading of microplastics (MPs) derived from industry, landfill, domestic waste water and storm water. The partitioning of MPs through the settlement ... -
Microplastics in the marine environment: analytical considerations, emerging sources, and protocol validation
(NUI Galway, 2024-02-02)Microplastics particles, with a size range between 1µm to 5 mm are established in all ecosystems, from the poles to the equator, and in a wide range of organisms including mammals, birds, fish, and invertebrates. ... -
The microprocessing factor DGCR8 interacts with ATM and functions independently of its partner DROSHA in the DDR
(NUI Galway, 2020-01-23)The eukaryotic cell has evolved a complex suite of mechanisms called the DNA damage response (DDR), that acts by sensing DNA damage and reacting appropriately to maintain genomic integrity. The PIK kinase ATM is a key ... -
MicroRNA expression in colorectal cancer.
(IOS Press, 2012-12-17)Colorectal cancer is a common disease entity with a multi-factorial aetiology which remains poorly understood. It is estimated that in 2008, colorectal cancerwas responsible for 8% of all cancer deaths, making it the fourth ... -
MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer
(Biomed Central, 2010)Background Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription ... -
Microrna expression profiling to identify and validate reference genes for relative quantification in colorectal cancer
(Springer Nature, 2010-04-29)Background: Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription ... -
Microrna signatures predict oestrogen receptor, progesterone receptor and her2/neureceptor status in breast cancer
(Springer Nature, 2009-05-11)Introduction Breast cancer is a heterogeneous disease encompassing a number of phenotypically diverse tumours. Expression levels of the oestrogen, progesterone and HER2/neu receptors which characterize clinically distinct ... -
Microrna-10a is reduced in breast cancer and regulated in part through retinoic acid
(Springer Nature, 2015-05-02)Background: MicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer. MicroRNA-10a ... -
Microrna-21 and pdcd4 expression in colorectal cancer
(Elsevier BV, 2011-07-01) -
Microrna-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced dna damage response through cdc7 kinase in lung cancer cells
(Springer Nature, 2013-07-01)Cdc7 kinase is a key regulator of DNA replication and has an important role in the cellular DNA damage response by controlling checkpoint signaling and cell survival. Yet, how the activity of Cdc7 kinase is regulated is ... -
Microrna-9 inhibition of cell proliferation and identification of novel mir-9 targets by transcriptome profiling in breast cancer cells
(American Society for Biochemistry & Molecular Biology (ASBMB), 2012-07-02)Although underexpression of miR-9 in cancer cells is reported in many cancer types, it is currently difficult to classify miR-9 as a tumor suppressor or an oncomir. We demonstrate that miR-9 expression is down-regulated ... -
microRNA-mediated intercellular communication in the primary breast tumour microenvironment
(2014-08-30)microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ... -
MicroRNAs as biomarkers and therapeutics in breast cancer
(2017-05-25)Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ... -
Micrornas as prognostic indicators and therapeutic targets: potential effect on breast cancer management
(American Association for Cancer Research (AACR), 2008-01-15)The discovery of microRNAs (miRNA) as novel modulators of gene expression has resulted in a rapidly expanding repertoire of molecules in this family, as reflected in the concomitant expansion of scientific literature. ... -
MicroRNAs for the treatment of breast cancer
(NUI Galway, 2024-01-12)MicroRNA-379 (miR-379) has been reported as a potent tumour suppressor miRNA with data supporting a potential therapeutic function in breast cancer. Despite this, the exact mechanism of action of miR-379 is still ... -
Micrornas in colorectal cancer: function, dysregulation and potential as novel biomarkers
(Elsevier BV, 2011-08-01) -
Microscale flow structures measured downstream of a mechanical heart valve
(Trinity College Dublin, 2010-01-22) -
Microscopic particle discrimination using spatially-resolved Fourier-holographic light scattering angular spectroscopy
(Optica, 2006-11-13)We utilize Fourier-holographic light scattering angular spectroscopy to record the spatially resolved complex angular scattering spectra of samples over wide fields of view in a single or few image captures. Without resolving ...