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Now showing items 5819-5838 of 14646
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Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation
(Cambridge University Press, 2018-01-09)Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component ... -
Genome dosage and parent of origin effects in a ploidy series of Arabidopsis thaliana
(2013-11-11)Polyploidy, the presence of more than two sets of chromosomes in an organism, plays major roles in plant evolution, development and function. Understanding the effects of polyploidization at the phenotypic and molecular ... -
Genome dosage, genetic hybridity and crop improvement
(NUI Galway, 2020-03-02)Plant breeding is focussed on introducing novel traits in plants, as well as enhancing or repressing traits already present. A noble objective in agriculture is to produce more food per unit area with overall fewer resources. ... -
Genome sequencing of the extinct eurasian wild aurochs, bos primigenius, illuminates the phylogeography and evolution of cattle
(Springer Nature, 2015-10-26)Background: Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus. While previous genetic studies have shed some light on the ... -
Genome, Environment, Microbiome and Metabolome in Autism (GEMMA) study design: Biomarkers identification for precision treatment and primary prevention of Autism Spectrum Disorders by an integrated multi-omics systems biology approach
(MDPI, 2020-10-16)Autism Spectrum Disorder (ASD) affects approximately 1 child in 54, with a 35-fold increase since 1960. Selected studies suggest that part of the recent increase in prevalence is likely attributable to an improved awareness ... -
Genome-wide association analysis identifies three new breast cancer susceptibility loci
(Springer Nature, 2012-01-22)Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for similar to 8% of the heritability of the disease. We attempted to replicate 72 ... -
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
(Springer Nature, 2015-03-09)Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining similar to 14% of the familial risk of the disease. To identify ... -
Genome-wide association mapping reveals that specific and pleiotropic regulatory mechanisms fine-tune central metabolism and growth in arabidopsis
(American Society of Plant Biologists (ASPB), 2017-09-27)Central metabolism is a coordinated network that is regulated at multiple levels by resource availability and by environmental and developmental cues. Its genetic architecture has been investigated by mapping metabolite ... -
Genome-wide association studies identify four er negative–specific breast cancer risk loci
(Springer Nature, 2013-03-27)Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are ... -
Genome-wide association study implicates hla-c*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia
(Elsevier BV, 2012-10-01)Background: We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods: The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 directly ... -
Genome-wide autozygosity is associated with lower general cognitive ability
(Springer Nature, 2015-09-22)Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose ... -
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
(Elsevier BV, 2015-01-01)Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive ... -
Genome-wide identification of novel micrornas and their target genes in the human parasite schistosoma mansoni
(Elsevier BV, 2011-08-01) -
Genome-wide microrna binding site variation between extinct wild aurochs and modern cattle identifies candidate microrna-regulated domestication genes
(Frontiers Media SA, 2017-01-31)The domestication of cattle from the now-extinct wild aurochs (Bos primigenius) involved selection for physiological and behavioral traits, with underlying genetic factors that remain largely unknown. Non coding microRNAs ... -
Genome-wide schizophrenia variant at mir137 does not impact white matter microstructure in healthy participants
(Elsevier BV, 2014-06-01) -
GenomeSnip: Fragmenting the Genomic Wheel to augment discovery in cancer research
(2014)Cancer genomics researchers have greatly benefited from high-throughput technologies for the characterization of genomic alterations in patients. These voluminous genomics datasets when supplemented with the appropriate ... -
GenomeSnip: Fragmenting the Genomic Wheel to augment discovery in cancer research
(ISCB, 2014-02-28)Cancer genomics researchers have greatly benefited from high-throughput technologies for the characterization of genomic alterations in patients. These voluminous genomics datasets when supplemented with the appropriate ... -
Genomic and transcriptomic investigations into the feed efficiency phenotype of beef cattle
(NUI Galway, 2019-03-06)Improving the feed efficiency of cattle is a method to increase profits while simultaneously reducing the environmental impact of beef production. Residual feed intake (RFI) is a measure of feed efficiency, calculated as ... -
The genomic architecture of nucleolar organiser regions on the short arms of human acrocentric chromosomes
(2015-09-29)Nucleolar Organiser Regions (NORs) are comprised of ribosomal gene (rDNA) arrays and adjacent sequences. Nucleoli, the sites of ribosome biogenesis and key regulators of cellular growth and proliferation, form around NORs. ... -
Genomic characterization of listeria monocytogenes isolates associated with clinical listeriosis and the food production environment in ireland
(MDPI AG, 2018-03-20)Listeria monocytogenes is a major human foodborne pathogen that is prevalent in the natural environment and has a high case fatality rate. Whole genome sequencing (WGS) analysis has emerged as a valuable methodology for ...