Browsing by Title
Now showing items 4584-4603 of 14645
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Estimation of the impact of CAP reform on the structure of farming in the disadvantaged areas of Ireland
(National University of Ireland, Galway, 1997-09)In this paper the Johansen model was used to examine the impact of CAP Reform on the structure of farming in the Disadvantaged Areas of Ireland. The model is essentially a policy impact model using an elasticity set. ... -
Estrogen deficiency alters the mechanobiological responses of osteoblasts and osteocytes
(NUI Galway, 2020-07-03)Osteoporosis is most commonly manifested following menopause when estrogen production is deficient and, as a result, bone loss and changes in bone composition occur leading to bone fractures. Estrogen inhibits bone ... -
estrogen deficiency attenuates fluid flow–induced [ca 2+ ] i oscillations and mechanoresponsiveness of mlo-y4 osteocytes
(FASEB, 2017-03-31)It has been proposed that estrogen regulates the mechanosensitivity of osteocytes; however, the effects of estrogen deficiency that arises during postmenopausal osteoporosis on mechanical stimulation induced calcium signaling ... -
Estrogen deficiency impairs integrin αvβ3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling
(Nature Research (part of Springer Nature), 2019-03-15)The integrin alpha(v)beta(3) has been shown to play an important role in osteocyte mechanotransduction. It has been reported that there are fewer beta(3) integrin-containing cells in osteoporotic bone cells. Osteocytes ... -
Estrogen induces repression of the breast cancer and salivary gland expression gene in an estrogen receptor dependent manner
(American Association for Cancer Research (AACR), 2008-01-01)The focus of this study is on the expression and regulation of the estrogen-regulated breast cancer and salivary gland expression (BASE) gene that may function as a breast cancer marker. In MCF7 cells, BASE is repressed ... -
Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro
(Thieme Publishing Group, 2011-11-28)In early postmenopausal women, estrogen withdrawal is associated with increased bone turnover leading to bone loss and increased risk of fracture. Recent studies have suggested that the remaining bone tissue is significantly ... -
Estrogen withdrawal in osteocytes results in altered integrin function, primary cilium elongation, and increased pro-osteoclastogenic signalling
(NUI Galway, 2020-06-28)Osteocytes are the main mechanosensitive cells within bone. They detect changes in the mechanical environment and transduce them into biochemical responses (RANKL, OPG, and sclerostin) that regulate bone remodelling by ... -
Estrogen withdrawal, increased breast cancer risk and the kras-variant
(Informa UK Limited, 2015-05-11)The KRAS-variant is a biologically functional, microRNA binding site variant, which predicts increased cancer risk especially for women. Because external exposures, such as chemotherapy, differentially impact the effect ... -
Ethical challenges in qualitative research: Examples from practice
(RCN Publishing Ltd., 2010-10-22)This article examines the many ethical challenges that are specific to qualitative research. These challenges concern the issues of informed consent procedures, the researcher-participant relationship, risk-benefit ratio, ... -
An ethical commitment: responsibility, cosmopolitanism and care in the internationalised university
(Routledge, 2013-10)The internationalization of higher education has decisively moved from being a scholarly tradition of mobility across borders to an almost purely economic concern. This is a trend that is most pronounced in countries such ... -
Ethical dilemmas in the development-security nexus: A human development and capabilities approach
(Centre for Global Education, 2019)The development-security nexus marks a paradigm shift for development, security and humanitarian practice, with implications for education and development education. This article explores zigzag changes, initially towards ... -
Ethical Issues in Internet Research: International Good Practice and Irish Research Ethics Documents
(Research-publishing.net, 2013)This chapter discusses the main research ethical concerns that arise in internet research and reviews existing research ethical guidance in the Irish context in relation to its application to internet research. The ... -
Ethical review and childrens research in Ireland
(OMCYA, 2010-03)A substantial increase in research into the lives of children has been experienced in Ireland over the last few years. This increase is not only in the amount of research undertaken but also in the multi-disciplinary range ... -
Ethics and assisted dying in the Republic of Ireland
(NUI Galway, 2021-09-13)‘Ethics and Assisted Dying in the Republic of Ireland’ argues that active assistance in dying can be morally permissible in limited contexts. Where an individual is suffering from an irremediable chronic or terminal illness ... -
The ethics of narrative form in Gaskell, Dickens, and Eliot
(2016-05-03)This thesis explores Elizabeth Gaskell’s North and South, Charles Dickens’s Our Mutual Friend, and George Eliot’s Daniel Deronda through the lens of rhetorical narratology to offer conclusions for realism, metafiction, and ... -
Ethnomethodology: Time for a revisit? A discussion paper
(Elsevier, 2007-07-05)The aim of this paper is to provide a comprehensive overview of ethnomethodology and explore its usefulness as a methodology for nursing. Ethnomethodology was conceived through the writings of Harold Garfinkel, an American ... -
Etiology of non–cystic fibrosis bronchiectasis in adults and its correlation to disease severity
(American Thoracic Society, 2015-12-01)Rationale: Testing for underlying etiology is a key part of bronchiectasis management, but it is unclear whether the same extent of testing is required across the spectrum of disease severity. Objectives: The aim of the ... -
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer
(Springer Nature, 2012-09-12)Introduction: The Ets-1 transcription factor is a candidate breast cancer oncogene that regulates the expression of genes involved in tumor progression and metastasis. Ets-1 signaling has also been linked to the development ... -
EU Bewildered by Ireland's Attitude to Peacekeeping Force for Macedonia
(The Irish Times, 2003)