Browsing by Title
Now showing items 3824-3843 of 14646
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Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease
(Wiley-Blackwell, 2005-07-01)Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial ... -
Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu.
(Nature Publishing Group, 2013-08)Investigations into cell therapies for application in organ transplantation have grown. Here, we describe the ex vivo generation of donor bone marrow-derived dendritic cells (BMDCs) and glucocorticoid-treated BMDCs with ... -
Donor bone marrow–derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu
(Elsevier BV, 2013-11-01)Investigations into cell therapies for application in organ transplantation have grown. Here, we describe the ex vivo generation of donor bone marrow-derived dendritic cells (BMDCs) and glucocorticoid-treated BMDCs with ... -
Don’t Look: Representations of Horror in the Twenty-First-Century Symposium, University of Edinburgh, 28 April 2018
(Intellect, 2018-10-01)Review of Don't Look: Representations of Horror in the Twenty-First-Century Symposium, University of Edinburgh, 28 April 2018 -
Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11c]nnc-112
(Springer Nature, 2008-10-22)The dopamine type-1 receptor has been implicated in major depressive disorder (MDD) by clinical and preclinical evidence from neuroimaging, post mortem, and behavioral studies. To date, however, selective in vivo assessment ... -
Dopaminergic-induced dyskinesia assessment based on a single belt-worn accelerometer
(Elsevier BV, 2016-02-01) -
Doping and anti-doping: the excesses of enterprise and the tyranny of transparency
(http://www.tandfonline.com/doi/full/10.1080/19406940.2015.1063529, 2015-07-06)Building on Foucault s theory of the enterprise society , this article situates the use of performance-enhancing drugs in sport in the wider socio-economic context, where generalised competition has become a strategic ... -
Doppeltes spiel: Selbstreflexive konfigurationsstrategien als gegenstand einer kritischen textpraxis digitaler spiele. Analysen und interpretationen zu Vagrant Story, Dark Souls III und Horizon: Zero Dawn
(NUI Galway, 2020-05-07)Seen as a comparatively recent phenomenon, digital games continue to challenge academic discourse. The study argues that digital games are best understood as both complex configurational practices as well as audio-visually ... -
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
(Karger Publishers, 2017-10-24)This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ... -
Double-breasting employee voice: an assessment of motives, arrangements and durability
(SAGE Publications, 2014-06-19)This article explores employee voice within the specific institutional arrangement of double-breasting. Double-breasting is when multi-plant organizations recognize trade unions in some company sites, with non-union ... -
Double-edged sword: a p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury
(Elsevier BV, 2012-06-01)Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of ... -
Double-strand breaks trigger mrx- and mec1-dependent, but tel1-independent, checkpoint activation
(Oxford University Press (OUP), 2006-08-01)Together with the Tel1 PI3 kinase, the Mre11/Rad50/Xrs2 (MRX) complex is involved in checkpoint activation in response to double-strand breaks (DSBs), a function also conserved in human cells by Mre11/Rad50/Nbs1 acting ... -
Double-voicing and rubber ducks: the dominance of English in the imaginative play of two bilingual sisters
(Taylor & Francis (Routledge), 2020-05-05)Through analysis of a video recording of two bilingual siblings playing with rubber ducks, this article explores the concept that imaginative play can serve as a potential site for language shift. The article argues that ... -
Doubly disadvantaged: Gender, spatially concentrated deprivation and nascent entrepreneurial activity
(Wiley, 2019-12-02)Drawing on human capital, intersectionality and mixed embeddedness theory, we test hypotheses on the relationship between gender differences in human capital and gender differences in nascent entrepreneurial activity across ... -
Doxorubicin induces the dna damage response in cultured human mesenchymal stem cells
(Springer Nature, 2012-10-18)Anthracyclines, including doxorubicin, are widely used in the treatment of leukemia. While the effects of doxorubicin on hematopoietic cells have been characterized, less is known about the response of human mesenchymal ... -
Dóchas an Dúchais: Neartú na nEalaíon Dúchais agus nGréasán Cultúrtha sa Ghaeilge
(Acadamh na hOllscolaíochta Gaeilge, Ollscoil na hÉireann, Gaillimh, 2016)Agus sinn ag plé leis an fhocal ealaín, b’fhéidir nach miste dúinn smaoineamh ar bhunús an fhocail féin sa Ghaeilge. Is focal é atá á úsáid sa tseanchiall sin sa Ghaeilge ar fad agus is mithid dúinn cialla an fhocail a ... -
DR. Joseph Fenn Sleigh to James Barry
(1763-12-31)Dr. Joseph Fenn Sleigh (1733-70), Quaker and art connoisseur, practised as a physician in Cork. He had attended the Quaker school at Ballitore soon after Edmund Burke was a pupil there and later studied medicine in ... -
Dr4 specific trail variants are more efficacious than wild-type trail in pancreatic cancer
(Informa UK Limited, 2014-11-20)Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since ... -
Dr4-selective tumor necrosis factor-related apoptosis-inducing ligand (trail) variants obtained by structure-based design
(American Society for Biochemistry & Molecular Biology (ASBMB), 2008-05-12)Tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL) is a potential anticancer agent that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR4 and DR5. TRAIL can ... -
Draft genome sequence of pigeonpea (cajanus cajan), an orphan legume crop of resource-poor farmers
(Springer Nature, 2011-11-06)Pigeonpea is an important legume food crop grown primarily by smallholder farmers in many semi-arid tropical regions of the world. We used the Illumina next-generation sequencing platform to generate 237.2 Gb of sequence, ...