Browsing by Author "Samali, Afshin"
Now showing items 21-40 of 65
-
Endoplasmic reticulum stress-mediated induction of sestrin 2 potentiates cell survival
Saveljeva, Svetlana; Cleary, Patricia; Mnich, Katarzyna; Ayo, Abiodun; Pakos-Zebrucka, Karolina; Patterson, John B.; Logue, Susan E.; Samali, Afshin (Impact Journals, LLC, 2016-02-22)Upregulation of SESTRIN 2 (SESN2) has been reported in response to diverse cellular stresses. In this study we demonstrate SESTRIN 2 induction following endoplasmic reticulum (ER) stress. ER stress-induced increases in ... -
Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development
Maurel, Marion; Samali, Afshin; Chevet, Eric (Elsevier BV, 2014-09-01)Steatohepatitis is a cause of hepatocellular carcinoma development; however, the underlying mechanisms are poorly defined. In this issue of Cancer Cell, Nakagawa and colleagues demonstrate that activation of endoplasmic ... -
Experimental african trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells
De Beule, Nathan; Menu, Eline; Bertrand, Mathieu J.M.; Favreau, Mérédis; De Bruyne, Elke; Maes, Ken; De Veirman, Kim; Radwanska, Magdalena; Samali, Afshin; Magez, Stefan; Vanderkerken, Karin; De Trez, Carl (Impact Journals, LLC, 2017-08-07)Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow (BM). Recently, several studies have highlighted the role of pathogens in either promoting or dampening malignancies ... -
Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine
Kavanagh, Edel T.; Loughlin, John P.; Herbert, Kate Reed; Dockery, Peter; Samali, Afshin; Doyle, Karen M.; Gorman, Adrienne M. (Elsevier BV, 2006-12-01) -
Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity
Carleton, Laura A.; Chakravarthy, Reka; van der Sloot, Almer M.; Mnich, Katarzyna; Serrano, Luis; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2017-11-03)Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ... -
Heat shock preconditioning protects against er stress-induced apoptosis through the regulation of the bh3-only protein bim
Kennedy, Donna; Mnich, Katarzyna; Samali, Afshin (Wiley-Blackwell, 2014-01-01) -
hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli
Samali, Afshin; Robertson, John D.; Peterson, Elisabeth; Manero, Florence; van Zeijl, Leone; Paul, Catherine; Cotgreave, Ian A.; Arrigo, André-Patrick; Orrenius, Sten (Springer Nature, 2001-01-01)Enhanced cell survival and resistance to apoptosis during thermotolerance correlates with an increased expression of heat shock proteins (Hsps). Here we present additional evidence in support of the hypothesis that the ... -
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction
Gupta, Sanjeev; Deepti, Ayswaria; Deegan, Shane; Samali, Afshin (2010)Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway ... -
Hspb1 facilitates erk-mediated phosphorylation and degradation of bim to attenuate endoplasmic reticulum stress-induced apoptosis
Kennedy, Donna; Mnich, Katarzyna; Oommen, Deepu; Chakravarthy, Reka; Almeida-Souza, Leonardo; Krols, Michiel; Saveljeva, Svetlana; Doyle, Karen M.; Gupta, Sanjeev; Timmerman, Vincent; Janssens, Sophie; Gorman, Adrienne M.; Samali, Afshin (Springer Nature, 2017-08-31)BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells ... -
Identification and validation of novel targets of regulated IRE1-dependent decay in triple negative breast cancer
Bolger, Alice (NUI Galway, 2023-08-16)Breast cancer is the most commonly diagnosed cancer in women. Triple-negative breast cancer (TNBC) refers to a subtype which lacks oestrogen receptors (ESR1), progesterone receptors (PR) and does not overexpress Human ... -
Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions
Mháille, Aoife Ní; McQuaid, Stephen; Windebank, Anthony; Cunnea, Paula; McMahon, Jill; Samali, Afshin; FitzGerald, Una (Oxford University Press (OUP), 2008-03-01)Activation of endoplasmic reticulum (ER) stress-related cell signals has been reported in several neurologic disorders and may contribute to neurodegeneration. Endoplasmic reticulum stress is also linked to ischemic injury. ... -
The integrated stress response
Pakos-Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M. (EMBO Press, 2016-09-14)In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation ... -
Investigating the role of IRE1α RNase activity in breast cancer
McGrath, Eoghan Patrick (NUI Galway, 2018-12-17)Metastatic, drug resistant disease poses the greatest threat to the survival of breast cancer patients. Thus, elucidating and targeting mechanisms which govern this phenotype is a primary goal of the breast cancer field. ... -
Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer
Cleary, Patricia (2015-09-18)X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress. Activation of the endoplasmic reticulum ... -
Kinase Inhibitor against Quiescent and Proliferating CLL Cells
Natoni, Alessandro; Murill, Laura S.; Kliszczak, Anna E.; Samali, Afshin; Santocanale, Corrado (2011-07-18)In chronic lymphocytic leukemia (CLL) the proliferation rate and resistance to drug-induced apoptosis are recognized as important factors in the outcome of treatment. In this study, we assess the activity and the mechanism ... -
Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by trail
Szegezdi, Eva; van der Sloot, Almer M.; Mahalingam, Devalingam; O'Leary, Lynda; Cool, Robbert H.; Muñoz, Inés G.; Montoya, Guillermo; Quax, Wim J.; de Jong, Steven; Samali, Afshin; Serrano, Luis (American Society for Biochemistry & Molecular Biology (ASBMB), 2012-01-02)Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ... -
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
Gupta, Sanjeev; Cuffe, Lorraine; Szegezdi, Eva; Logue, Susan E.; Neary, Catherine; Healy, Sandra; Samali, Afshin (2010)During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ... -
Mediators of endoplasmic reticulum stress-induced apoptosis
Szegezdi, Eva; Logue, Susan E; Gorman, Adrienne M.; Samali, Afshin (Wiley-Blackwell, 2006-09-01)The efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ... -
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment
Mylotte, Louise A.; Duffy, Angela M.; Murphy, Mary; O'Brien, Timothy; Samali, Afshin; Barry, Frank; Szegezdi, Eva (Wiley-Blackwell, 2008-05-01)The application of mesenchyrnal stem cells (MSCs) for myocardial repair following ischemic injury is of strong interest, but current knowledge regarding the survival and retention of differentiation potency of stem cells ... -
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
Samali, Afshin; FitzGerald, Una; Deegan, Shane; Gupta, Sanjeev (2010)The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ...