Browsing by Subject "Medicine"
Now showing items 21-40 of 234
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Cartilage repair in a rabbit model: Development of a novel subchondral defect and assessment of early cartilage repair using a rabbit mesenchymal stem cell seeded scaffold
(2018-02-14)Purpose: To develop a subchondral defect in a rabbit model and assess cartilage repair using a mesenchymal stem cell-seeded scaffold. Materials and Methods: To achieve this goal, a bovine explant model and two pilot ... -
Cervical lymphadenopathy in lung cancer
(NUI Galway, 2021-09-18)Overall, in the thesis we showed that cervical lymphadenopathy is frequently present in patients with lung cancer and mediastinal lymphadenopathy on CT to a degree that justifies screening for it routinely. We have shown ... -
Changes in anthropometric and metabolic outcomes during and after a milk-based meal replacement programme in bariatric patients
(NUI Galway, 2020-04-14)During this work, I examined a cohort of patients with severe and complicated obesity undergoing a milk-based intensive weight management programme, examining changes in various traits in the short and medium term. Firstly, ... -
Changing diet and physical activity behaviour in type 2 diabetes
(NUI Galway, 2022-03-14)The aim of this thesis was to design an artefact to support diet and physical activity behaviour change in people with type 2 diabetes. The first step was to identify behaviour change techniques (BCTs) in diet and physical ... -
Characterisation and analysis of Memory T-cells in COVID-19 patient sample
(NUI Galway, 2023-08-08)Background: Immunological memory is the key to long-term protection against disease. It is the hallmark of adaptive immunity which facilitates an accelerated and enhanced immune response against a pathogen encountered ... -
Characterisation of sex differences in behavioural domains and antidepressant response in two rat models of depression
(NUI Galway, 2018-10-17)Although the rate of depression is known to be almost twice as high in women compared to men, most evaluation of antidepressant efficacy involved only males until the early 1990s. In pre-clinical depression research male ... -
Characterisation of the molecular and functional changes exerted on human bone marrow mesenchymal stem cells by prostate cancer cells
(2016-07-01)Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. MSCs reside in various areas such as the bone marrow, ... -
Characterisation of triple negative breast carcinoma and identification of the value of immunohistochemical markers and stromal tumour infiltrating lymphocytes
(NUI Galway, 2017-10)Breast cancer is a complex disease that encompasses multiple molecular subtypes that have different clinical behavior. The behavior can be influenced by both the characteristics of the cancer cells as well as the surrounding ... -
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
(NUI Galway, 2018-12-14)Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ... -
Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype
(2015-11-05)Prostate cancer is the second most commonly diagnosed cancer, and ranked third in the causes of death from cancer in Irish men. Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 ... -
Commonly prescribed anti-depressants: What clinicians need to know
(The Psychological Society of Ireland (PSI), 2011-10)According to two Cochrane collaboration reviews (Moncrieff, Wessely, & Hardy, 2004; Turner, Mathews, Linardatos, Tell, & Rosenthal, 2008), the efficacy of modern antidepressants has yet to be conclusively demonstrated ... -
A compendium of the steps required to complete 13 essential procedural skills
(University of Galway, 2022-09)Entrustable Professional Activities (EPAs) are units of professional practice that capture essential competencies in which trainees must become proficient before undertaking them independently. EPAs provide supervisors ... -
A continuous pressure monitoring technology for biomedical applications
(NUI Galway, 2023-11-10)The diverse physiological pressures within the human body are crucial in maintaining optimal health and homeostasis. Long-term and continuous monitoring of these physiological pressures can provide key information in ... -
A core outcome set for the treatment of pregnant women with pregestational diabetes: An international consensus study
(NUI Galway, 2021-09-10)Background Meaningful comparisons between studies evaluating interventions of pregnant women with pre-gestational diabetes mellitus (PGDM) are limited due to the heterogeneity in outcome selection and reporting. The aim ... -
Current and potential diagnostic modalities in the detection and management of breast cancer
(NUI Galway, 2021-07-06)Global statistics have demonstrated that breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among female patients, accounting for 23 percent of total cancer cases and 14 percent of ... -
The design, manufacture and testing of a composite polysialic acid mimetic peptide loaded collagen nerve graft for use in peripheral nerve repair
(NUI Galway, 2016-02-15)Peripheral nerve injuries can be debilitating for patients. The current gold-standard technique for peripheral nerve repair is autograft. This procedure involves harvesting a non-critical nerve from a donor site from the ... -
Developing a three dimensional (3D) in vitro model of adrenocortical carcinoma (ACC)
(NUI Galway, 2024-04-05)Adrenocortical carcinoma (ACC) is a rare orphan disease and a rare cancer which carries a poor prognosis. The only licensed pharmacological treatment is mitotane, an insecticide. Typically, 2D cell culture models have ... -
Developing and characterizing cellular models for neurodegenerative diseases.
(2016-05-13)The focus of this work was to develop and validate in vitro cell culture models of neurodegenerative diseases, with a focus on Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease characterized ... -
Development and evaluation of an assessment tool for identification of elements of situation awareness in OSCEs in undergraduate medical curricula
(NUI Galway, 2018-07-20)Situation awareness (SA) is recognised as an important factor in patient safety and clinical decision making in conjunction with diagnostic and therapeutic reasoning. Missed diagnosis and treatment errors have been identified ...