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Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in sprague-dawley rats
(Wiley-Blackwell, 2016-11-11)
In addition to its role in regulating energy homeostasis, the adipokine leptin modifies gastrointestinal (GI) function. Indeed, leptin-resistant obese humans and leptin-deficient obese mice exhibit altered GI motility. In ...
An enzymatic ruler modulates lewis antigen glycosylation of helicobacter pylori lps during persistent infection
(Proceedings of the National Academy of Sciences, 2006-02-13)
Helicobacter pylori persistently colonizes about half the human population and contributes to the development of peptic ulcer disease and gastric cancer. This organism has evolved means to structurally alter its surface ...
Compartmental oxidation of thiol–disulphide redox couples during epidermal growth factor signalling
(Portland Press Ltd., 2005-03-01)
Exogenously added ROS (reactive oxygen species) cause generalized oxidation of cellular components, whereas endogenously generated ROS induced by physiological stimuli activate discrete signal transduction pathways. ...
Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity
(Springer Nature, 2016-03-11)
In this study, on/off markers for intervertebral disc (IVD) and articular cartilage (AC) cells (chondrocytes) and distinct glycoprofiles of cell and tissue-types were identified from immaturity to maturity. Three and eleven ...
The role of transferrin saturation as a screening test for hereditary haemochromatosis in an irish population seeking medical care
(SAGE Publications, 2003-03-01)
Background Genetic studies have indicated a high prevalence of mutations for hereditary haemochromatosis (HH) in Irish populations. Given the high cost of genetic screening and the ethical implications thereof, we assessed ...
Diverse populations of t cells with nk cell receptors accumulate in the human intestine in health and in colorectal cancer
(Wiley-Blackwell, 2004-08-01)
T cells expressing INK cell receptors (NKR) display rapid MHC-unrestricted cytotoxicity and potent cytokine secretion and are thought to play roles in immunity against tumors. We have quantified and characterized NKR+ T ...
Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons
(Public Library of Science (PLoS), 2013-06-03)
Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ...
Subclinical detection of diabetic cardiomyopathy with micrornas: challenges and perspectives
(Hindawi Limited, 2016-01-01)
The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a ...
Role ofhelicobacter pylori rfajgenes (hp0159 and hp1416) in lipopolysaccharide synthesis
(Oxford University Press (OUP), 2004-12-01)
Gene-eluting stents: adenovirus-mediated delivery of enos to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
(Elsevier BV, 2008-10-01)
Drug-eluting stents for coronary artery disease results in inhibition of smooth muscle cell (SMC) and endothelial cells which may increase the risk of stent thrombosis. In this study, we attempted to enhance re-endothelialization ...