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Cb1 and cb2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice
(Oxford University Press (OUP), 2013-08-19)
Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal ...
Sar150640, a selective β3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis
(Wiley-Blackwell, 2010-02-05)
Background and purpose:
The uterine pathophysiology underlying inflammatory conditions such as chorioamnionitis remains largely unclear. As we have shown that beta(3)-adrenoceptors act as regulators of myometrial inflammation, ...
Facets of diazotrophy in the oxygen minimum zone waters off peru
(Springer Nature, 2014-05-09)
Nitrogen fixation, the biological reduction of dinitrogen gas (N-2) to ammonium (NH4+), is quantitatively the most important external source of new nitrogen (N) to the open ocean. Classically, the ecological niche of oceanic ...
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
(Springer Nature, 2016-06-21)
Background: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk.
Method: We performed a fine-scale ...
Robust, efficient, and practical electrogene transfer method for human mesenchymal stem cells using square electric pulses
(Mary Ann Liebert Inc, 2013-10-01)
Mesenchymal stem cells (MSCs) are multipotent nonhematopoietic cells with the ability to differentiate into various specific cell types, thus holding great promise for regenerative medicine. Early clinical trials have ...
Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-tnfα drug
(Elsevier BV, 2015-09-01)
Evidence for intron length conservation in a set of mammalian genes associated with embryonic development
(Springer Nature, 2011-01-01)
Background: We carried out an analysis of intron length conservation across a diverse group of nineteen mammalian species. Motivated by recent research suggesting a role for time delays associated with intron transcription ...
Distinct mechanisms underlie oral vs aboral regeneration in the cnidarianhydractinia echinata
(eLife Sciences Organisation, Ltd., 2015-04-17)
Cnidarians possess remarkable powers of regeneration, but the cellular and molecular mechanisms underlying this capability are unclear. Studying the hydrozoan Hydractinia echinata we show that a burst of stem cell proliferation ...
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer Nature, 2014-11-15)
Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ...
Genome-wide microrna binding site variation between extinct wild aurochs and modern cattle identifies candidate microrna-regulated domestication genes
(Frontiers Media SA, 2017-01-31)
The domestication of cattle from the now-extinct wild aurochs (Bos primigenius) involved selection for physiological and behavioral traits, with underlying genetic factors that remain largely unknown. Non coding microRNAs ...