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Mnsod protects colorectal cancer cells from trail-induced apoptosis by inhibition of smac/diablo release
(Springer Nature, 2007-07-23)
The mitochondrial enzyme manganese superoxide dismutase (MnSOD) has been shown to have two faces with regard to its role in tumor development. On the one side, it is well documented that overexpression of MnSOD slows down ...
Microrna signatures predict oestrogen receptor, progesterone receptor and her2/neureceptor status in breast cancer
(Springer Nature, 2009-05-11)
Introduction Breast cancer is a heterogeneous disease encompassing a number of phenotypically diverse tumours. Expression levels of the oestrogen, progesterone and HER2/neu receptors which characterize clinically distinct ...
Bioconductorbuntu: a linux distribution that implements a web-based dna microarray analysis server
(Oxford University Press (OUP), 2009-03-23)
BioconductorBuntu is a custom distribution of Ubuntu Linux that automatically installs a server-side microarray processing environment, providing a user-friendly web-based GUI to many of the tools developed by the Bioconductor ...
Mouse induced pluripotent stem cells
(UPV/EHU Press, 2008-01-01)
The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Kif4), represents ...
Effect of progesterone on embryo survival
(Cambridge University Press (CUP), 2008-07-07)
Increased genetic selection over the past 40 years has resulted in a dairy cow with an improved biological efficiency for producing milk but with an associated reduced fertility. Embryo loss is the greatest factor contributing ...
A non-apoptotic role for caspase-9 in muscle differentiation
(The Company of Biologists, 2008-10-28)
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role ...
Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome
(Wiley-Blackwell, 2009-02-01)
Objective. Tumor necrosis factor receptor (TNFR) -associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSFIA gene. Unlike other autoinflammatory diseases ...
Newly identified genetic risk variants for celiac disease related to the immune response
(Springer Nature, 2008-03-02)
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in ...
Salivary muc7 is a major carrier of blood group i type o-linked oligosaccharides serving as the scaffold for sialyl lewis x
(Oxford University Press (OUP), 2008-11-29)
Isolation of salivary MUC7 with gel electrophoresis allowed analysis by LC-MS and LC-MS(2) of released O-linked oligosaccharides and a thorough description of the glycosylation of this molecule, where high-molecular-weight ...