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Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons
(Public Library of Science (PLoS), 2013-06-03)
Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ...
Alcohol-attributable mortality in ireland
(Oxford University Press (OUP), 2010-06-07)
Aims: The study aim was to calculate Irish alcohol-attributable fractions (AAFs) and to apply these measurements to existing data in order to quantify the impact of alcohol on mortality. Methods: Exposure of the Irish ...
Effects of increasing levothyroxine on pregnancy outcomes in women with uncontrolled hypothyroidism
(Wiley-Blackwell, 2016-08-23)
Objective Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse ...
Increased risk of cognitive and functional decline in patients with atrial fibrillation: results of the ontarget and transcend studies
(Joule Inc., 2012-02-27)
Background: The role of atrial fibrillation in cognitive impairment and dementia, independent of stroke, is uncertain. We sought to determine the association of atrial fibrillation with cognitive and physical impairment ...
Heritability in the efficiency of nonsense-mediated mrna decay in humans
(Public Library of Science (PLoS), 2010-07-21)
Background: In eukaryotes mRNA transcripts of protein-coding genes in which an intron has been retained in the coding region normally result in premature stop codons and are therefore degraded through the nonsense-mediated ...
Detection of ros induced proteomic signatures by mass spectrometry
(Frontiers Media SA, 2017-07-07)
Reversible and irreversible post-translational modifications ( PTMs) induced by endogenously generated reactive oxygen species (ROS) in regulatory enzymes and proteins plays an essential role in cellular signaling. Almost ...
Biopolymer-based nanoparticles for cystic fibrosis lung gene therapy studies
(MDPI AG, 2018-01-13)
Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, optimal delivery of emerging therapeutics to airway epithelial cells ...
Symmetry difference electrical impedance tomography - a novel modality for anomaly detection
(IOP Publishing, 2018-03-13)
Objective: The theoretical basis, experimental implementation, and proof of concept of a novel electrical impedance tomography (EIT) imaging technique, called symmetry difference EIT, is described. This technique is ...
Occurrence and co-occurrence of hallucinations by modality in schizophrenia-spectrum disorders
(Elsevier BV, 2017-06-01)
It is not only unclear why hallucinations in schizophrenia occur with different prevalence by modality, but also to what extent they do. Reliable prevalence estimates of hallucinations by modality in schizophrenia are ...