Now showing items 21-30 of 102
Effects of levothyroxine therapy on pregnancy outcomes in women with subclinical hypothyroidism
(Mary Ann Liebert Inc, 2016-07-01)
Background: Subclinical hypothyroidism (SCH) has been associated with increased risk of adverse pregnancy outcomes in some, but not all, studies. Uncertainty remains regarding the impact of levothyroxine (LT4) therapy on ...
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
(Springer Nature, 2015-02-05)
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with ...
Molecular profiling: a case of zbtb16-rara acute promyelocytic leukemia
(Hindawi Limited, 2017-01-01)
Several variant RARA translocations have been reported in acute promyelocytic leukemia (APL) of which the t(11;17)(q23;q21), which results in a ZBTB16-RARA fusion, is the most widely identified and is largely resistant to ...
Simple method for comparing reliability of two serum tumour markers in breast carcinoma.
Aims-To compare the two breast tumour markers, CA15-3 and mucinous-like carcinoma associated antigen (MCA), using Receiver Operating Characteristic (ROC) curve analysis. Methods-One hundred and ninety six patients ...
The role of transferrin saturation as a screening test for hereditary haemochromatosis in an irish population seeking medical care
(SAGE Publications, 2003-03-01)
Background Genetic studies have indicated a high prevalence of mutations for hereditary haemochromatosis (HH) in Irish populations. Given the high cost of genetic screening and the ethical implications thereof, we assessed ...
Symmetry difference electrical impedance tomography - a novel modality for anomaly detection
(IOP Publishing, 2018-03-13)
Objective: The theoretical basis, experimental implementation, and proof of concept of a novel electrical impedance tomography (EIT) imaging technique, called symmetry difference EIT, is described. This technique is ...
Occurrence and co-occurrence of hallucinations by modality in schizophrenia-spectrum disorders
(Elsevier BV, 2017-06-01)
It is not only unclear why hallucinations in schizophrenia occur with different prevalence by modality, but also to what extent they do. Reliable prevalence estimates of hallucinations by modality in schizophrenia are ...
Identification and validation of mirnas as endogenous controls for rq-pcr in blood specimens for breast cancer studies
(Public Library of Science (PLoS), 2013-12-31)
Introduction: A prerequisite to accurate interpretation of RQ-PCR data is robust data normalization. A commonly used method is to compare the cycle threshold (C-T) of target miRNAs with those of a stably expressed endogenous ...
Lack of association between kir and hla-c type and susceptibility to idiopathic bronchiectasis
(Elsevier BV, 2014-08-01)
Heberden's nodes and what heberden could not see: the pivotal role of ligaments in the pathogenesis of early nodal osteoarthritis and beyond
(Oxford University Press (OUP), 2008-04-04)
Despite its relatively high prevalence, polyarticular nature, limited treatment options and recognized genetic contribution, the study of generalized OA (GOA) has lagged behind that of isolated knee OA. Whilst the pathogenesis ...