Search
Now showing items 11-20 of 22
The apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
(Wiley-Blackwell, 2009-06-04)
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed ...
Mnsod protects colorectal cancer cells from trail-induced apoptosis by inhibition of smac/diablo release
(Springer Nature, 2007-07-23)
The mitochondrial enzyme manganese superoxide dismutase (MnSOD) has been shown to have two faces with regard to its role in tumor development. On the one side, it is well documented that overexpression of MnSOD slows down ...
Mesenchymal stem cells expressing trail lead to tumour growth inhibition in an experimental lung cancer model
(Wiley-Blackwell, 2008-03-29)
Lung cancer is a major public health problem in the western world, and gene therapy strategies to tackle this disease systemically are often impaired by inefficient delivery of the vector to the tumour tissue. Some of the ...
Stem cells are resistant to trail receptor-mediated apoptosis
(Wiley-Blackwell, 2009-11-01)
New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ...
A non-apoptotic role for caspase-9 in muscle differentiation
(The Company of Biologists, 2008-10-28)
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role ...
Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome
(Wiley-Blackwell, 2009-02-01)
Objective. Tumor necrosis factor receptor (TNFR) -associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSFIA gene. Unlike other autoinflammatory diseases ...
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment
(Wiley-Blackwell, 2008-05-01)
The application of mesenchyrnal stem cells (MSCs) for myocardial repair following ischemic injury is of strong interest, but current knowledge regarding the survival and retention of differentiation potency of stem cells ...
Histone deacetylase inhibitors cooperate with ifn-γ to restore caspase-8 expression and overcome trail resistance in cancers with silencing of caspase-8
(Springer Nature, 2009-07-13)
Evasion of apoptosis can be caused by epigenetic silencing of caspase-8, a key component of the extrinsic apoptosis pathway. Loss of caspase-8 correlates with poor prognosis in medulloblastoma, which highlights the relevance ...
The mitochondrial death pathway: a promising therapeutic target in diseases
(Wiley-Blackwell, 2009-07-01)
The mitochondrial pathway to apoptosis is a major pathway of physiological cell death in vertebrates. The mitochondrial cell death pathway commences when apoptogenic molecules present between the outer and inner mitochondrial ...
Caspases as therapeutic targets
(Wiley-Blackwell, 2008-09-01)
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; ...