Now showing items 1-10 of 18
Identification and validation of oncologic mirna biomarkers for luminal a-like breast cancer
(Public Library of Science (PLoS), 2014-01-31)
Introduction: Breast cancer is a common disease with distinct tumor subtypes phenotypically characterized by ER and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression, and altered ...
Facets of diazotrophy in the oxygen minimum zone waters off peru
(Springer Nature, 2014-05-09)
Nitrogen fixation, the biological reduction of dinitrogen gas (N-2) to ammonium (NH4+), is quantitatively the most important external source of new nitrogen (N) to the open ocean. Classically, the ecological niche of oceanic ...
Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistantstaphylococcus aureusstrain lac
(Oxford University Press (OUP), 2014-04-01)
Community-associated methicillin-resistant Staphylococcus aureus of the USA300 lineage is emerging as an important cause of medical device-related infection. However, few factors required for biofilm accumulation by USA300 ...
A collagen-based scaffold delivering exogenous microrna-29b to modulate extracellular matrix remodeling
(Elsevier BV, 2014-04-01)
Directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies. Thus, antifibrotic interfering RNA (RNAi) therapy with exogenous microRNA (miR)-29B was proposed as a method to modulate ...
A role for pparα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats
Background and PurposeThe nuclear hormone receptor, PPAR, and its endogenous ligands, are involved in pain modulation. PPAR is expressed in the medial prefrontal cortex (mPFC), a key brain region involved in both the ...
Co-acting gene networks predict trail responsiveness of tumour cells with high accuracy
(Springer Nature, 2014-01-01)
Background: Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction ...
The expression and roles of nde1 and ndel1 in the adult mammalian central nervous system
(Elsevier BV, 2014-06-01)
In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (flt3) ligand in hematopoietic development
(Ferrata Storti Foundation (Haematologica), 2014-01-24)
Cytokines are essential regulators of hematopoiesis, acting in an instructive or permissive way. Fms-like tyrosine kinase 3 ligand (FLT3L) is an important cytokine for the development of several hematopoietic populations. ...
Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain
(Royal Society of Chemistry (RSC), 2014-01-01)
The purpose of this study was to develop a platform transfection technology, for applications in the brain, which could transfect astrocytes without requiring cell specific functionalization and without the common cause ...
Development of a cucumis sativus tilling platform for forward and reverse genetics
(Public Library of Science (PLoS), 2014-05-16)
Background: Cucumber (Cucumis sativus) belongs to the Cucurbitaceae family that includes more than 800 species. The cucumber genome has been recently sequenced and annotated. Transcriptomics and genome sequencing of many ...