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Identification of novel cis-regulatory elements of eya1 in xenopus laevis using bac recombineering
(Springer Nature, 2017-11-03)
The multifunctional Eya1 protein plays important roles during the development of cranial sensory organs and ganglia, kidneys, hypaxial muscles and several other organs in vertebrates. Eya1 is encoded by a complex locus ...
Ulk4 is essential for ciliogenesis and csf flow
(Society for Neuroscience, 2016-07-20)
Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three ...
Loss of sigb in listeria monocytogenes strains egd-e and 10403s confers hyperresistance to hydrogen peroxide in stationary phase under aerobic conditions
(American Society for Microbiology, 2016-05-20)
SigB is the main stress gene regulator in Listeria monocytogenes affecting the expression of more than 150 genes and thus contributing to multiple-stress resistance. Despite its clear role in most stresses, its role in ...
Divergent evolution of the activity and regulation of the glutamate decarboxylase systems in listeria monocytogenes egd-e and 10403s: roles in virulence and acid tolerance
(Public Library of Science (PLoS), 2014-11-11)
The glutamate decarboxylase (GAD) system has been shown to be important for the survival of Listeria monocytogenes in low pH environments. The bacterium can use this faculty to maintain pH homeostasis under acidic conditions. ...
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
(Springer Nature, 2013-03-27)
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for similar to 9% of the familial risk of the ...
Genome-wide association studies identify four er negative–specific breast cancer risk loci
(Springer Nature, 2013-03-27)
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are ...
Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm
(The Company of Biologists, 2012-02-08)
It is still controversial whether cranial placodes and neural crest cells arise from a common precursor at the neural plate border or whether placodes arise from non-neural ectoderm and neural crest from neural ectoderm. ...
Cloning, overexpression in escherichia coli, and characterization of a thermostable fungal acetylxylan esterase from talaromyces emersonii
(American Society for Microbiology, 2012-03-09)
The gene encoding an acetylxylan esterase (AXE1) from the thermophilic ascomycete Talaromyces etnersonii was cloned, expressed in Escherichia coli, and characterized. This form of AXE1, rTeAXE1, exhibits increased ...
Tumor microenvironment-based feed-forward regulation of nos2 in breast cancer progression
(Proceedings of the National Academy of Sciences, 2014-04-14)
Inflammation is widely recognized as an inducer of cancer progression. The inflammation-associated enzyme, inducible nitric oxide synthase (NOS2), has emerged as a candidate oncogene in estrogen receptor (ER)-negative ...