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Clinical and immunological risk factors associated withhaemophilus influenzaetype b conjugate vaccine failure in childhood
(Oxford University Press (OUP), 2000-10-01)
Haemophilus influenzae type b (Hib) conjugate vaccines have proved extremely efficacious in healthy children. True Hib vaccine failures are rare. Hib conjugate vaccines were introduced for routine immunization in the United ...
Homocysteine toxicity in escherichia coli is caused by a perturbation of branched-chain amino acid biosynthesis
(American Society for Microbiology, 2005-06-20)
In Escherichia coli the sulfur-containing amino acid homocysteine (Hcy) is the last intermediate on the methionine hiosynthetic pathway. Supplementation of a glucose-based minimal medium with Hcy at concentrations greater ...
Human metapneumovirus-associated respiratory tract infections in the republic of ireland during the influenza season of 2003–2004
(Elsevier BV, 2005-05-01)
Human metapneumovirus (hMPV) is a newly identified paramyxovirus that has been associated with respiratory tract illness in children aged < 5 years, the elderly, and immunocompromised patients. This study determined the ...
Plakoglobin expression and localization in zebrafish embryo development
(Portland Press Ltd., 2004-11-01)
Plakoglobin (gamma-catenin) and beta-catenin are major components of the adherens junctions and can be localized to the nucleus by activation of the Wnt signalling pathway. In addition, plakoglobin is also found in desmosomes, ...
Evaluation of the diagnostic utility of spinal magnetic resonance imaging in axial spondylarthritis
(Wiley-Blackwell, 2009-05-01)
Objective. Magnetic resonance imaging (MRI) is increasingly used for the diagnosis of axial spondylarthritis (SpA), but it is unknown whether characteristic lesions are actually specific for SpA. This study was undertaken ...
Genetic diversity of the fish pathogen aeromonas salmonicida demonstrated by random amplified polymorphic dna and pulsed-field gel electrophoresis analyses
(Inter-Research Science Center, 2000-01-01)
The current taxonomy of Aeromonas salmonicida includes 4 subspecies. A. salmonicida subsp. salmonicida is associated with salmonid furunculosis, and A. salmonicida subsp, achromogenes, A. salmonicida subsp. masoucida, and ...
The role of transferrin saturation as a screening test for hereditary haemochromatosis in an irish population seeking medical care
(SAGE Publications, 2003-03-01)
Background Genetic studies have indicated a high prevalence of mutations for hereditary haemochromatosis (HH) in Irish populations. Given the high cost of genetic screening and the ethical implications thereof, we assessed ...
Heberden's nodes and what heberden could not see: the pivotal role of ligaments in the pathogenesis of early nodal osteoarthritis and beyond
(Oxford University Press (OUP), 2008-04-04)
Despite its relatively high prevalence, polyarticular nature, limited treatment options and recognized genetic contribution, the study of generalized OA (GOA) has lagged behind that of isolated knee OA. Whilst the pathogenesis ...
The effects of blood–brain barrier disruption on glial cell function in multiple sclerosis: figure 1
(Portland Press Ltd., 2009-02-01)
Dysfunction of the BBB (blood-brain barrier) is a major hallmark of MS (multiple sclerosis). Studies in our laboratories over the last decade have shown that increased 131313 permeability is associated with decreased ...