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Electrochemiluminescent array to detect oxidative damage in ds-dna using [os(bpy)2(phen-benz-cooh)]2+/nafion/graphene films
(American Chemical Society (ACS), 2016-03-25)
Reactive oxygen species (ROS) oxidize guanosines in DNA to form 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), a biomarker for oxidative stress. Herein we describe a novel 64-microwell electrochemiluminescent (ECL) array ...
Ligand-free noble metal nanocluster catalysts on carbon supports via “soft” nitriding
(American Chemical Society (ACS), 2016-04-13)
We report a robust, universal "soft" nitriding method to grow in situ ligand-free ultrasmall noble metal nanocatalysts (UNMN; e.g., Au, Pd, and Pt) onto carbon. Using low-temperature urea pretreatment at ...
Electrochemiluminescence arrays for studies of metabolite-related toxicity
(Wiley-Blackwell, 2016-06-01)
This article reviews recent progress from our laboratory in electrochemiluminescence (ECL) arrays designed for screening toxicity-related chemistry of chemical and drug candidates. Cytochrome P450s and metabolic bioconjugation ...
Electrochemistry-based approaches to low cost, high sensitivity, automated, multiplexed protein immunoassays for cancer diagnostics
(Royal Society of Chemistry (RSC), 2016-01-01)
Early detection and reliable diagnostics are keys to effectively design cancer therapies with better prognoses. The simultaneous detection of panels of biomarker proteins holds great promise as a general tool for reliable ...
Fast nucleation for silica nanoparticle synthesis using a sol–gel method
(Royal Society of Chemistry (RSC), 2016-01-01)
We have developed a method that for the first time allowed us to synthesize silica particles in 20 minutes using a sol-gel preparation. Therefore, it is critically important to understand the synthesis mechanism and kinetic ...
Electrocatalytic oxidation of alcohols, tripropylamine, and dna with ligand-free gold nanoclusters on nitrided carbon
(Wiley-Blackwell, 2016-07-20)
Electrocatalytic properties of ligand-free gold nanoclusters (AuNCs, <2nm) grown on nitrided carbon supports (denoted as AuNCs@N-C) were evaluated for the oxidation of representative organic molecules including ...
Electrochemiluminescence at bare and dna-coated graphite electrodes in 3d-printed fluidic devices
(American Chemical Society (ACS), 2016-02-26)
Clear plastic fluidic devices with ports for incorporating electrodes to enable electrochemiluminescence (ECL) measurements were prepared using a low-cost, desktop three-dimensional (3D) printer based on stereolithography. ...
Microfluidic array for simultaneous detection of dna oxidation and dna-adduct damage
(Royal Society of Chemistry (RSC), 2016-01-01)
Exposure to chemical pollutants and pharmaceuticals may cause health issues caused by metabolite-related toxicity. This paper reports a new microfluidic electrochemical sensor array with the ability to simultaneously detect ...
Multiplex immunosensor arrays for electrochemical detection of cancer biomarker proteins
(Wiley-Blackwell, 2016-06-07)
Measuring panels of protein biomarkers offer a new personalized approach to early cancer detection, disease monitoring and patients' response to therapy. Multiplex electrochemical methods are uniquely positioned to provide ...
High-throughput electrochemical microfluidic immunoarray for multiplexed detection of cancer biomarker proteins
(American Chemical Society (ACS), 2016-08-26)
Microchip-based microfluidic electrochemical arrays hold great promise for fast, high-throughput multiplexed detection of cancer biomarker proteins at low cost per assay using relatively simple instrumentation. Here we ...