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Evolution of a research field—a micro (rna) example
(PeerJ, 2015-03-17)
Background. Every new scientific field can be traced back to a single, seminal publication. Therefore, a bibliometric analysis can yield significant insights into the history and potential future of a research field. This ...
Prediction of breast cancer risk based on profiling with common genetic variants
(Oxford University Press (OUP), 2015-04-02)
Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. ...
Metastatic breast cancer: the potential of mirna for diagnosis and treatment monitoring
(Springer Nature, 2015-02-27)
Breast cancer affects approximately 12 % women worldwide and results in 14 % of all cancer-related fatalities. Breast cancer is commonly categorized into one of four main subtypes (luminal A, luminal B, human epidermal ...
Height and breast cancer risk: evidence from prospective studies and mendelian randomization
(Oxford University Press (OUP), 2015-08-20)
Background: Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, ...
Awareness and uptake of family screening in patients diagnosed with colorectal cancer at a young age
(Hindawi Limited, 2015-01-01)
Background. One-fifth of people who develop colorectal cancer (CRC) have a first-degree relative (FDR) also affected. There is a large disparity in guidelines for screening of relatives of patients with CRC. Herein we ...
Identification of novel genetic markers of breast cancer survival
(Oxford University Press (OUP), 2015-04-18)
Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with ...
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating mirnas
(Public Library of Science (PLoS), 2015-09-10)
Introduction
Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed ...
An evaluation of the use of deliberate practice and simulation to train interns in requesting blood products
(Ovid Technologies (Wolters Kluwer Health), 2015-04-01)
Introduction: Technical or practical skills deficits upon graduation from medical school are prevalent and contribute to increasing medical error. The current study sought to evaluate the efficacy of a simulation-and ...
Inherited variants in the inner centromere protein (incenp) gene of the chromosomal passenger complex contribute to the susceptibility of er-negative breast cancer
(Oxford University Press (OUP), 2015-01-13)
The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. The present candidate gene approach investigates the ...