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Identification and characterization of novel associations in the casp8/als2cr12 region on chromosome 2 with breast cancer risk
(Oxford University Press (OUP), 2014-08-28)
Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this ...
Lack of association between kir and hla-c type and susceptibility to idiopathic bronchiectasis
(Elsevier BV, 2014-08-01)
Genetic diversity and associated pathology of rhabdovirus infections in farmed and wild perch perca fluviatilis in ireland
(Inter-Research Science Center, 2014-12-02)
Rhabdovirus infections are an emerging problem for both wild and farmed freshwater fish in Northern Europe. In October 2005, a clinical outbreak with an approximate mortality rate of 40% occurred in a single batch of ...
Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development
(Elsevier BV, 2014-09-01)
Steatohepatitis is a cause of hepatocellular carcinoma development; however, the underlying mechanisms are poorly defined. In this issue of Cancer Cell, Nakagawa and colleagues demonstrate that activation of endoplasmic ...
Biological insights from 108 schizophrenia-associated genetic loci
(Springer Nature, 2014-07-22)
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a ...
Therapeutic use of dolls for people living with dementia: a critical review of the literature
(SAGE Publications, 2014-08-25)
Background: There are a number of therapies currently available to assist healthcare professionals and carers with non-pharmacological treatment for people living with dementia. One such therapy that has been growing in ...
Mirna signature of unfolded protein response in h9c2 rat cardiomyoblasts
(Springer Nature, 2014-01-01)
Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ...
Elevated herv-k mrna expression in pbmc is associated with a prostate cancer diagnosis particularly in older men and smokers
(Oxford University Press (OUP), 2014-05-23)
Aberrant expression of subgroup k human endogenous retroviruses (HERV-K) has been observed in prostate cancer. This subgroup is unique because it encodes sequences in the human genome containing open reading frames for ...
Therapeutic use of compression stockings for orthostatic hypotension: an assessment of patient and physician perspectives and practices
(Oxford University Press (OUP), 2014-10-24)
Background: elastic compression stockings (ECS) can be used as a non-pharmacological therapeutic option for older patients with orthostatic hypotension (OH). We aimed to investigate the practices and views of patients and ...
Effectiveness of a smartphone application to promote physical activity in primary care: the smart move randomised controlled trial
(Royal College of General Practitioners, 2014-06-30)
Background
Physical inactivity is a major, potentially modifiable, risk factor for cardiovascular disease, cancer, and other chronic diseases. Effective, simple, and generalisable interventions that will increase physical ...