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Red algal extracts from plocamium lyngbyanum and ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae
(Springer Nature, 2018-05-16)
Through the current trend for bioprospecting, marine organisms-particularly algae-are becoming increasingly known for their osteogenic potential. Such organisms may provide novel treatment options for osteoporosis and other ...
Centrobin controls primary ciliogenesis in vertebrates
(Rockefeller University Press, 2018-02-13)
The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNT ROB in hTERT-RPE1 cells and observed an increased ...
Role of micro-rnas in breast cancer surgery
(Wiley-Blackwell, 2018-01-01)
Background: The management of breast cancer has changed dramatically in the molecular era. Micro-RNAs can contribute to multiple facets of cancer surgery.
Methods: This narrative review, based on years of research on the ...
Anti-cancer activity of phenyl and pyrid-2-yl 1,3-substituted benzo[1,2,4]triazin-7-ones and stable free radical precursors
(MDPI AG, 2018-03-03)
Cell viability studies for benzo[1,2,4]triazin-7-ones and 1,2,4-benzotriazinyl (Blatter-type) radical precursors are described with comparisons made with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). All of the stable free ...
Vitamin d receptor variants and uncontrolled asthma
(Edra SpA, 2018-01-01)
Background. Asthma is a common childhood respiratory disease, affecting around 20% of Irish children. In other populations, vitamin D receptor (VDR) polymorphisms have been associated with asthma risk. We aimed to investigate ...
Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury
(American Association for the Advancement of Science (AAAS), 2018-04-01)
Painful intervertebral disc degeneration is mediated by inflammation that modulates glycosylation and induces hyperinnervation and sensory sensitization, which result in discogenic pain. Hyaluronic acid (HA) used as a ...