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Identification of novel cis-regulatory elements of eya1 in xenopus laevis using bac recombineering
(Springer Nature, 2017-11-03)
The multifunctional Eya1 protein plays important roles during the development of cranial sensory organs and ganglia, kidneys, hypaxial muscles and several other organs in vertebrates. Eya1 is encoded by a complex locus ...
Genome-wide microrna binding site variation between extinct wild aurochs and modern cattle identifies candidate microrna-regulated domestication genes
(Frontiers Media SA, 2017-01-31)
The domestication of cattle from the now-extinct wild aurochs (Bos primigenius) involved selection for physiological and behavioral traits, with underlying genetic factors that remain largely unknown. Non coding microRNAs ...
Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
(Frontiers Media SA, 2017-08-21)
Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ...
Differential impact of hormone receptor status on survival and recurrence for her2 receptor-positive breast cancers treated with trastuzumab
(Springer Nature, 2017-04-04)
Introduction Hormone receptor status has major implications for treatment and survival of breast cancer. Yet the impact of hormone receptor status on outcome after Trastuzumab has received little attention. The objective ...
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
(Springer Nature, 2017-10-23)
Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease(1). We conducted a GWAS using 21,468 ER-negative ...
Signatures derived from increase in sharpin gene copy number are associated with poor prognosis in patients with breast cancer
(Elsevier BV, 2017-08-01)
We report three signatures produced from SHARPIN gene copy number increase (GCN-Increase) and their effects on patients with breast cancer (BC). In the Metabric dataset (n = 2059, cBioPortal), SHARPIN GCN-Increase occurs ...
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix
(Springer Nature, 2017-03-27)
The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation, differentiation and metastasis. In multiple myeloma (MM), interactions ...
Association analysis identifies 65 new breast cancer risk loci
(Springer Nature, 2017-10-23)
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ...
<i>phip</i> - a novel candidate breast cancer susceptibility locus on 6q14.1
(Impact Journals, LLC, 2017-11-28)
Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent ...
Towards precision medicine: discovering novel gynecological cancer biomarkers and pathways using linked data
(Springer Nature, 2017-09-19)
Background: Next Generation Sequencing (NGS) is playing a key role in therapeutic decision making for the cancer prognosis and treatment. The NGS technologies are producing a massive amount of sequencing datasets. Often, ...