Now showing items 1-10 of 478
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity
(Informa UK Limited, 2014-09-02)
Somatic cells senesce in culture after a finite number of divisions indefinitely arresting their proliferation. DNA damage and senescence increase the cellular number of centrosomes, the 2 microtubule organizing centers ...
Population genetics inference for longitudinally-sampled mutants under strong selection
(Genetics Society of America, 2014-09-10)
Longitudinal allele frequency data are becoming increasingly prevalent. Such samples permit statistical inference of the population genetics parameters that influence the fate of mutant variants. To infer these parameters ...
The reform study protocol: a cohort randomised controlled trial of a multifaceted podiatry intervention for the prevention of falls in older people
Introduction: Falls and fall-related injuries are a serious cause of morbidity and cost to society. Foot problems and inappropriate footwear may increase the risk of falls; therefore podiatric interventions may play a role ...
Benthos distribution modelling and its relevance for marine ecosystem management
(Oxford University Press (OUP), 2014-06-19)
Marine benthic ecosystems are difficult to monitor and assess, which is in contrast to modern ecosystem-based management requiring detailed information at all important ecological and anthropogenic impact levels. Ecosystem ...
Drinking motives and links to alcohol use in 13 european countries
(Alcohol Research Documentation, Inc., 2014-05-01)
Objective: The purpose of this study was to test the structure and endorsement of drinking motives and their links to alcohol use among 11- to 19-year-olds from 13 European countries. Method: Confirmatory factor analysis, ...
Coupling of amine-containing osmium complexes and glucose oxidase with carboxylic acid polymer and carbon nanotube matrix to provide enzyme electrodes for glucose oxidation
(The Electrochemical Society, 2014-09-04)
The immobilization methodology of enzyme and redox complex on electrode surfaces can have an impact on the magnitude and stability of amperometric current response, with implications for application as biosensor and fuel ...
Specific ion effects on macromolecular interactions inescherichia coliextracts
Protein characterization in situ remains a major challenge for protein science. Here, the interactions of Tat-GB1 in Escherichia coli cell extracts were investigated by NMR spectroscopy and size exclusion chromatography ...
Towards a molecular description of disease; a systems biology approach in osteoarthritis
(Elsevier BV, 2014-04-01)
Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models
(Springer Nature, 2014-01-01)
Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional ...