Now showing items 1-10 of 101
Migrastatin analogues inhibit canine mammary cancer cell migration and invasion
(Public Library of Science (PLoS), 2013-10-08)
Background: Cancer spread to other organs is the main cause of death of oncological patients. Migration of cancer cells from a primary tumour is the crucial step in the complex process of metastasis, therefore blocking ...
Early growth response-1 is a regulator of dr5-induced apoptosis in colon cancer cells
(Springer Nature, 2010-01-19)
A gene regulatory network underlying the formation of pre-placodal ectoderm in xenopus laevis
(Springer Nature, 2018-07-16)
Background: The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm. Many sensory organs and ganglia of vertebrates develop ...
Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development
Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression ...
Single nucleotide polymorphisms within the bovine dlk1-dio3 imprinted domain are associated with economically important production traits in cattle
(Oxford University Press (OUP), 2010-09-03)
Previous studies show that DNA sequence variation within the mammalian DLK1-DIO3 imprinted domain influences production traits in domestic livestock, most notably the ovine callipyge phenotype. We assessed genotype-phenotype ...
Thiamine plays a critical role in the acid tolerance of listeria monocytogenes
(Oxford University Press (OUP), 2011-11-14)
Understanding the molecular basis of acid tolerance in the food-borne pathogen Listeria monocytogenes is important as this property contributes to survival in the food-chain and enhances survival within infected hosts. The ...
Identification of novel cis-regulatory elements of eya1 in xenopus laevis using bac recombineering
(Springer Nature, 2017-11-03)
The multifunctional Eya1 protein plays important roles during the development of cranial sensory organs and ganglia, kidneys, hypaxial muscles and several other organs in vertebrates. Eya1 is encoded by a complex locus ...
Control of tnf-induced dendritic cell maturation by hybrid-type n-glycans
(The American Association of Immunologists, 2011-03-21)
The activity of alpha-1,2-mannosidase I is required for the conversion of high-mannose to hybrid-type (ConA reactive) and complex-type N-glycans (Phaseolus vulgaris-leukoagglutinin [PHA-L] reactive) during posttranslational ...
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors
(Springer Nature, 2015-08-25)
Introduction: Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, ...