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Elevated herv-k mrna expression in pbmc is associated with a prostate cancer diagnosis particularly in older men and smokers
(Oxford University Press (OUP), 2014-05-23)
Aberrant expression of subgroup k human endogenous retroviruses (HERV-K) has been observed in prostate cancer. This subgroup is unique because it encodes sequences in the human genome containing open reading frames for ...
Modelling drug release from polymer-free coronary stents with microporous surfaces
(Elsevier BV, 2017-12-01)
Traditional coronary drug-eluting stents (DES) are made from metal and are coated with a permanent polymer film containing an anti-proliferative drug. Subsequent to stent deployment in a diseased coronary artery, the drug ...
Differential mirna expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers
(The Endocrine Society, 2011-05-01)
Background: Omental fat accumulation is associated with development of the metabolic syndrome, although its molecular characteristics are poorly understood. Mi(cro)RNAs (miRNAs), a class of small noncoding RNAs, are known ...
Mirna signature of unfolded protein response in h9c2 rat cardiomyoblasts
(Springer Nature, 2014-01-01)
Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ...
An evaluation of on-tool shrouds for controlling respirable crystalline silica in restoration stone work
(Oxford University Press (OUP), 2014-09-26)
Objectives: The task of grinding sandstone with a 5-inch angle grinder is a major source of exposure to respirable crystalline silica (RCS), known to cause diseases such as silicosis and lung cancer among workers who work ...
Benefit of social support for resilience-building is contingent on social context: examining cardiovascular adaptation to recurrent stress in women
(Informa UK Limited, 2012-07-01)
Previous work on social support and stress tolerance using laboratory-based cardiovascular stress response paradigms has suggested that perceived social support may be effective in building resilience in recipients. However, ...
Determinants of respirable crystalline silica exposure among stoneworkers involved in stone restoration work
(Oxford University Press (OUP), 2013-08-31)
Objectives: Crystalline silica occurs as a significant component of many traditional materials used in restoration stonework, and stoneworkers who work with these materials are potentially exposed to stone dust containing ...
Therapeutic use of compression stockings for orthostatic hypotension: an assessment of patient and physician perspectives and practices
(Oxford University Press (OUP), 2014-10-24)
Background: elastic compression stockings (ECS) can be used as a non-pharmacological therapeutic option for older patients with orthostatic hypotension (OH). We aimed to investigate the practices and views of patients and ...
Antimicrobial susceptibility of flavobacterium psychrophilum from chilean salmon farms and their epidemiological cut-off values using agar dilution and disk diffusion methods
(Frontiers Media SA, 2016-11-25)
Flavobacterium psychrophilum is the most important bacterial pathogen for freshwater farmed salmonids in Chile. The aims of this study were to determine the susceptibility to antimicrobials used in fish farming of Chilean ...
Perk-dependent repression of mir-106b-25 cluster is required for er stress-induced apoptosis
(Springer Nature, 2012-06-01)
Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ...