Now showing items 571-575 of 575
Ncoa3 coactivator is a transcriptional target of xbp1 and regulates perk–eif2α–atf4 signalling in breast cancer
(Springer Nature, 2016-04-25)
XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about ...
High-resolution imaging of ph in alkaline sediments and water based on a new rapid response fluorescent planar optode
(Springer Nature, 2016-05-20)
A new dual-lumophore optical sensor combined with a robust RGB referencing method was developed for two-dimensional (2D) pH imaging in alkaline sediments and water. The pH sensor film consisted of a proton-permeable polymer ...
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
(Springer Nature, 2016-11-21)
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We ...
Novel genetic loci underlying human intracranial volume identified through genome-wide association
(Springer Nature, 2016-10-03)
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a ...
The Irish National Adverse Events Study (INAES): the frequency and nature of adverse events in Irish hospitals—a retrospective record review study
Introduction Irish healthcare has undergone extensive change recently with spending cuts and a focus on quality initiatives; however, little is known about adverse event occurrence. Objective To assess the frequency and ...