Now showing items 531-535 of 535
Anti-gd2-ch14.18/cho coated nanoparticles mediate glioblastoma (gbm)-specific delivery of the aromatase inhibitor, letrozole, reducing proliferation, migration and chemoresistance in patient-derived gbm tumor cells
(Impact Journals, LLC, 2017-03-06)
Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We tested the hypothesis that targeted aromatase inhibition in ...
Sophisticated clean air strategies required to mitigate against particulate organic pollution
(Springer Nature, 2017-03-17)
Since the 1980's, measures mitigating the impact of transboundary air pollution have been implemented successfully as evidenced in the 1980-2014 record of atmospheric sulphur pollution over the NE-Atlantic, a key region ...
Human-centered design study: enhancing the usability of a mobile phone app in an integrated falls risk detection system for use by older adult users
(JMIR Publications Inc., 2017-05-30)
Background: Design processes such as human-centered design (HCD), which involve the end user throughout the product development and testing process, can be crucial in ensuring that the product meets the needs and capabilities ...
Gwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium
(Springer Nature, 2017-01-17)
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these ...
Cognitive characterization of schizophrenia risk variants involved in synaptic transmission: evidence of cacna1c's role in working memory
(Springer Nature, 2017-06-13)
With 4100 common variants associated with schizophrenia risk, establishing their biological significance is a priority. We sought to establish cognitive effects of risk variants at loci implicated in synaptic transmission ...