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Establishment of the european meningococcal strain collection genome library (emsc-gl) for the 2011 to 2012 epidemiological year
(European Centre for Disease Control and Prevention (ECDC), 2018-05-17)
Invasive meningococcal disease surveillance in Europe combines isolate characterisation and epidemiological data to support public health intervention. A representative European Meningococcal Strain Collection (EMSC) of ...
Development and performance evaluation of a recombinase polymerase amplification assay for the rapid detection of group b streptococcus
(Springer Nature, 2016-09-22)
Background: Despite the implementation of prevention guidelines, group B Streptococcal (GBS) infection remains a leading cause of sepsis, pneumonia, and meningitis, resulting in significant neonatal morbidity and mortality. ...
Stabilization of metastatic lesions affecting the second cervical vertebra
(Medknow, 2015-01-01)
Purpose: Metastatic spine disease is an ever-increasing burden on health care systems. Certain levels in the spine confer unique biomechanical characteristics and hence are of interest. Isolated C2 lesions are rare. We ...
Biological insights from 108 schizophrenia-associated genetic loci
(Springer Nature, 2014-07-22)
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a ...
Soft robotic sleeve supports heart function
(American Association for the Advancement of Science (AAAS), 2017-01-18)
There is much interest in form-fitting, low-modulus, implantable devices or soft robots that can mimic or assist in complex biological functions such as the contraction of heart muscle. We present a soft robotic sleeve ...
Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons
(Public Library of Science (PLoS), 2013-06-03)
Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ...
Vspipe, an integrated resource for virtual screening and hit selection: applications to protein tyrosine phospahatase inhibition
(MDPI AG, 2018-02-07)
The use of computational tools for virtual screening provides a cost-efficient approach to select starting points for drug development. We have developed VSpipe, a user-friendly semi-automated pipeline for structure-based ...
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
(Wiley-Blackwell, 2016-02-27)
The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ...
Analysis of correlation between an accelerometer-based algorithm for detecting parkinsonian gait and updrs subscales
(Frontiers Media SA, 2017-09-01)
Background: Our group earlier developed a small monitoring device, which uses accelerometer measurements to accurately detect motor fluctuations in patients with Parkinson's (On and Off state) based on an algorithm that ...
Oral paricalcitol reduces the prevalence of posttransplant hyperparathyroidism: results of an open label randomized trial
(Wiley-Blackwell, 2013-04-19)
Postkidney transplant hyperparathyroidism is a significant problem. Vitamin D receptor agonists are known to suppress parathyroid hormone (PTH) secretion. We examined the effect of oral paricalcitol on posttransplant ...