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Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development
(Elsevier BV, 2014-09-01)
Steatohepatitis is a cause of hepatocellular carcinoma development; however, the underlying mechanisms are poorly defined. In this issue of Cancer Cell, Nakagawa and colleagues demonstrate that activation of endoplasmic ...
Detection and management of diabetes in england: results from the health survey for england
(Springer Nature, 2017-09-25)
Introduction: As part of a control strategy current guidance in the UK recommends more intense surveillance of HbA1C levels among those of South-east Asian or Chinese ethnicity above specified BMI thresholds. The objective ...
Plakoglobin expression and localization in zebrafish embryo development
(Portland Press Ltd., 2004-11-01)
Plakoglobin (gamma-catenin) and beta-catenin are major components of the adherens junctions and can be localized to the nucleus by activation of the Wnt signalling pathway. In addition, plakoglobin is also found in desmosomes, ...
Soft robotic sleeve supports heart function
(American Association for the Advancement of Science (AAAS), 2017-01-18)
There is much interest in form-fitting, low-modulus, implantable devices or soft robots that can mimic or assist in complex biological functions such as the contraction of heart muscle. We present a soft robotic sleeve ...
Stabilization of metastatic lesions affecting the second cervical vertebra
(Medknow, 2015-01-01)
Purpose: Metastatic spine disease is an ever-increasing burden on health care systems. Certain levels in the spine confer unique biomechanical characteristics and hence are of interest. Isolated C2 lesions are rare. We ...
Surgical management of metastatic lesions at the cervicothoracic junction
(Medknow, 2015-01-01)
Purpose: The cervicothoracic junction (CTJ) represents a transition from the semirigid thoracic spine to the mobile subaxial cervical spine. Pathologic lesions are prone to kyphotic deformity. The aim of this study was to ...
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
(Wiley-Blackwell, 2016-02-27)
The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ...
Vspipe, an integrated resource for virtual screening and hit selection: applications to protein tyrosine phospahatase inhibition
(MDPI AG, 2018-02-07)
The use of computational tools for virtual screening provides a cost-efficient approach to select starting points for drug development. We have developed VSpipe, a user-friendly semi-automated pipeline for structure-based ...
Oral paricalcitol reduces the prevalence of posttransplant hyperparathyroidism: results of an open label randomized trial
(Wiley-Blackwell, 2013-04-19)
Postkidney transplant hyperparathyroidism is a significant problem. Vitamin D receptor agonists are known to suppress parathyroid hormone (PTH) secretion. We examined the effect of oral paricalcitol on posttransplant ...
Analysis of correlation between an accelerometer-based algorithm for detecting parkinsonian gait and updrs subscales
(Frontiers Media SA, 2017-09-01)
Background: Our group earlier developed a small monitoring device, which uses accelerometer measurements to accurately detect motor fluctuations in patients with Parkinson's (On and Off state) based on an algorithm that ...