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Surgical management of metastatic lesions at the cervicothoracic junction
(Medknow, 2015-01-01)
Purpose: The cervicothoracic junction (CTJ) represents a transition from the semirigid thoracic spine to the mobile subaxial cervical spine. Pathologic lesions are prone to kyphotic deformity. The aim of this study was to ...
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
(Wiley-Blackwell, 2016-02-27)
The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ...
Vspipe, an integrated resource for virtual screening and hit selection: applications to protein tyrosine phospahatase inhibition
(MDPI AG, 2018-02-07)
The use of computational tools for virtual screening provides a cost-efficient approach to select starting points for drug development. We have developed VSpipe, a user-friendly semi-automated pipeline for structure-based ...
Oral paricalcitol reduces the prevalence of posttransplant hyperparathyroidism: results of an open label randomized trial
(Wiley-Blackwell, 2013-04-19)
Postkidney transplant hyperparathyroidism is a significant problem. Vitamin D receptor agonists are known to suppress parathyroid hormone (PTH) secretion. We examined the effect of oral paricalcitol on posttransplant ...
Analysis of correlation between an accelerometer-based algorithm for detecting parkinsonian gait and updrs subscales
(Frontiers Media SA, 2017-09-01)
Background: Our group earlier developed a small monitoring device, which uses accelerometer measurements to accurately detect motor fluctuations in patients with Parkinson's (On and Off state) based on an algorithm that ...
Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled chart-1 clinical trial
(Oxford University Press (OUP), 2016-12-23)
Aims Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed ...
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the lung safe prospective cohort study
(Elsevier BV, 2017-08-01)
Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of ...
Biological insights from 108 schizophrenia-associated genetic loci
(Springer Nature, 2014-07-22)
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a ...
Molecular profiling: a case of zbtb16-rara acute promyelocytic leukemia
(Hindawi Limited, 2017-01-01)
Several variant RARA translocations have been reported in acute promyelocytic leukemia (APL) of which the t(11;17)(q23;q21), which results in a ZBTB16-RARA fusion, is the most widely identified and is largely resistant to ...