Now showing items 21-30 of 86
Identification and validation of mirnas as endogenous controls for rq-pcr in blood specimens for breast cancer studies
(Public Library of Science (PLoS), 2013-12-31)
Introduction: A prerequisite to accurate interpretation of RQ-PCR data is robust data normalization. A commonly used method is to compare the cycle threshold (C-T) of target miRNAs with those of a stably expressed endogenous ...
Lack of association between kir and hla-c type and susceptibility to idiopathic bronchiectasis
(Elsevier BV, 2014-08-01)
Multidimensional severity assessment in bronchiectasis: an analysis of seven european cohorts
Introduction Bronchiectasis is a multidimensional disease associated with substantial morbidity and mortality. Two disease-specific clinical prediction tools have been developed, the Bronchiectasis Severity Index (BSI) and ...
Detection of ros induced proteomic signatures by mass spectrometry
(Frontiers Media SA, 2017-07-07)
Reversible and irreversible post-translational modifications ( PTMs) induced by endogenously generated reactive oxygen species (ROS) in regulatory enzymes and proteins plays an essential role in cellular signaling. Almost ...
Gene therapy: pursuing restoration of dermal adhesion in recessive dystrophic epidermolysis bullosa
The replacement of a defective gene with a fully functional copy is the goal of the most basic gene therapy. Recessive dystrophic epidermolysis bullosa (RDEB) is characterised by a lack of adhesion of the epidermis to the ...
Biopolymer-based nanoparticles for cystic fibrosis lung gene therapy studies
(MDPI AG, 2018-01-13)
Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, optimal delivery of emerging therapeutics to airway epithelial cells ...
Long-term costs of introducing hpv-dna post-treatment surveillance to national cervical cancer screening in ireland
(Informa UK Limited, 2015-09-17)
Introduction: Co-testing (cytology plus human papillomavirus DNA testing) as part of cervical cancer surveillance in Ireland increases one-time testing costs. Of interest to policy makers was the long-term impact of these ...
Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled chart-1 clinical trial
(Oxford University Press (OUP), 2016-12-23)
Aims Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed ...