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Global effects of homocysteine on transcription in escherichia coli: induction of the gene for the major cold-shock protein, cspa
(Microbiology Society, 2006-08-01)
Homocysteine (Hey) is a thiol-containing amino acid that is considered to be medically important because it is linked to the development of several life-threatening diseases in humans, including cardiovascular disease and ...
An enzymatic ruler modulates lewis antigen glycosylation of helicobacter pylori lps during persistent infection
(Proceedings of the National Academy of Sciences, 2006-02-13)
Helicobacter pylori persistently colonizes about half the human population and contributes to the development of peptic ulcer disease and gastric cancer. This organism has evolved means to structurally alter its surface ...
Compartmental oxidation of thiol–disulphide redox couples during epidermal growth factor signalling
(Portland Press Ltd., 2005-03-01)
Exogenously added ROS (reactive oxygen species) cause generalized oxidation of cellular components, whereas endogenously generated ROS induced by physiological stimuli activate discrete signal transduction pathways. ...
The role of transferrin saturation as a screening test for hereditary haemochromatosis in an irish population seeking medical care
(SAGE Publications, 2003-03-01)
Background Genetic studies have indicated a high prevalence of mutations for hereditary haemochromatosis (HH) in Irish populations. Given the high cost of genetic screening and the ethical implications thereof, we assessed ...
Diverse populations of t cells with nk cell receptors accumulate in the human intestine in health and in colorectal cancer
(Wiley-Blackwell, 2004-08-01)
T cells expressing INK cell receptors (NKR) display rapid MHC-unrestricted cytotoxicity and potent cytokine secretion and are thought to play roles in immunity against tumors. We have quantified and characterized NKR+ T ...
Role ofhelicobacter pylori rfajgenes (hp0159 and hp1416) in lipopolysaccharide synthesis
(Oxford University Press (OUP), 2004-12-01)
Gene-eluting stents: adenovirus-mediated delivery of enos to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
(Elsevier BV, 2008-10-01)
Drug-eluting stents for coronary artery disease results in inhibition of smooth muscle cell (SMC) and endothelial cells which may increase the risk of stent thrombosis. In this study, we attempted to enhance re-endothelialization ...
Cutting edge: il-7 regulates the peripheral pool of adult ror + lymphoid tissue inducer cells
(The American Association of Immunologists, 2009-07-27)
During fetal life, CD4(+)CD3(-) lymphoid tissue inducer (LTi) cells are required for lymph node and Peyer's patch development in mice. In adult animals, CD4(+) CD3(-) cells are found in low numbers in lymphoid organs. ...
Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia
(Springer Nature, 2009-09-30)
A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing ...
Enhanced antitumor efficacy of a dr5-specific trail variant over recombinant human trail in a bioluminescent ovarian cancer xenograft model
(American Association for Cancer Research (AACR), 2009-03-10)
Purpose: Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) is clinically evaluated as novel anticancer drug. rhTRAIL-DR5, a rhTRAIL variant that specifically binds to DR5 receptor, has ...