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Methotrexate and lung disease in rheumatoid arthritis: a meta-analysis of randomized controlled trials
Objective. Methotrexate has shown efficacy for the treatment of several diseases, especially rheumatoid arthritis (RA). Methotrexate has also been implicated as a causative agent in interstitial lung disease. Patients with ...
Assessing methods to specify the target difference for a randomised controlled trial: delta (difference elicitation in trials) review
(National Institute for Health Research, 2014-01-01)
Background: The randomised controlled trial (RCT) is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to the design and validity of a RCT is a calculation of ...
Leakage inductance calculation for planar transformers with a magnetic shunt
(Institute of Electrical and Electronics Engineers (IEEE), 2014-11-01)
The magnetic shunt is generally inserted in a planar transformer to increase the leakage inductance, which can be utilized as the series inductor in resonant circuits such as the LLC resonant converter. This paper presents ...
Higher order dynamic inequalities on time scales
(Element d.o.o., 2014-01-01)
In this paper, we will prove some new dynamic inequalities of higher orders on time scales. The results contain some continuous and discrete inequalities as special cases. We will prove the results by making use of Holder's ...
Pb isotope compositions of detrital k-feldspar grains in the upper-middle yangtze river system: implications for sediment provenance and drainage evolution
The upper-middle Yangtze River drains the Qiangtang Block, the Songpan-Ganzi, the Yangtze Craton, and the Qinling-Dabie orogenic belt. These tectonic units have been shown to have heterogeneous Pb isotopic compositions, ...
Some dynamic inequalities of hardy type on time scales
(Element d.o.o., 2014-01-01)
In this paper we prove some new dynamic inequalities of Hardy type on time scales. The main results will be proved using algebraic inequalities, Holder inequality and Keller's chain rule on time scales.
Constitutive activation of ectodermal β-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure
(Public Library of Science (PLoS), 2014-03-19)
Vertebrate limbs originate from the lateral plate mesoderm (LPM) and the overlying ectoderm. While normal limb formation in defined regions has been well studied, the question of whether other positions retain limb-forming ...
Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development
Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression ...
Mscs isolated from patients with ischemic vascular disease have normal angiogenic potential
(Elsevier BV, 2014-11-01)