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Mutations in the genes for oocyte-derived growth factors gdf9 and bmp15 are associated with both increased ovulation rate and sterility in cambridge and belclare sheep (ovis aries)1
(Oxford University Press (OUP), 2004-04-01)
Belclare and Cambridge are prolific sheep breeds, the origins of which involved selecting ewes with exceptionally high litter size records from commercial flocks. The variation in ovulation rate in both breeds is consistent ...
Role of listeria monocytogenes b in survival of lethal acidic conditions and in the acquired acid tolerance response
(American Society for Microbiology, 2003-05-01)
The food-borne pathogen Listeria monocytogenes can acquire enhanced resistance to lethal acid conditions through multiple mechanisms. We investigated contributions of the stress-responsive alternative sigma factor, or ...
Meta-analysis confirms bcl2 is an independent prognostic marker in breast cancer
(Springer Nature, 2008-05-29)
Background: A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed ...
Micrornas as prognostic indicators and therapeutic targets: potential effect on breast cancer management
(American Association for Cancer Research (AACR), 2008-01-15)
The discovery of microRNAs (miRNA) as novel modulators of gene expression has resulted in a rapidly expanding repertoire of molecules in this family, as reflected in the concomitant expansion of scientific literature. ...
Evolution of astacin-like metalloproteases in animals and their function in development
(Wiley-Blackwell, 2006-03-01)
Astacin-like metalloproteases are ubiquitous in the animal kingdom but their phylogenetic relationships and ancient functions within the Metazoa are unclear. We have cloned and characterized four astacin-like cDNAs from ...
Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
(Royal Society of Chemistry (RSC), 2009-01-01)
The conjugation of carbohydrates to synthetic scaffolds has the goal of preparing potent inhibitors of lectin binding. We herein report the synthesis of a panel of bivalent compounds (cyclophane and terephthalamide-derivatives) ...
Insulin-like growth factor (igf) signalling is required for early dorso-anterior development of the zebrafish embryo
(UPV/EHU Press, 2004-01-01)
The insulin-like growth factor (IGF) signalling pathway has been highly conserved in animal evolution and, in mammals and Xenopus, plays a key role in embryonic growth and development, with the IGF-1 receptor (IGF-1R) being ...
Lewis x structures in the o antigen side-chain promote adhesion of helicobacter pylori to the gastric epithelium
(Wiley-Blackwell, 2002-01-18)
Helicobacter pylori NCTC11637 expresses a lipopolysaccharide (LPS) that comprises an O antigen side-chain with structural homology to the human blood group antigen Lewis X (Le(x)). The role of this molecule in adhesion of ...
Specific pgf2αreceptor (fp) antagonism and human uterine contractilityin vitro
(Wiley-Blackwell, 2005-08-01)
Objective PGF(2 alpha) acts through its receptor, FP, as an important smooth muscle contractile agent. The aim of this study was to investigate the effects of specific FP antagonism, using the novel-specific FP non-competitive ...