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Now showing items 141-145 of 145
Targeting the pim kinases in multiple myeloma
(Springer Nature, 2015-07-17)
Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine/threonine kinases with increased expression ...
New roles for nanos in neural cell fate determination revealed by studies in a cnidarian
(The Company of Biologists, 2013-05-09)
Nanos is a pan-metazoan germline marker, important for germ cell development and maintenance. In flies, Nanos also acts in posterior and neural development, but these functions have not been demonstrated experimentally in ...
Salivary muc7 is a major carrier of blood group i type o-linked oligosaccharides serving as the scaffold for sialyl lewis x
(Oxford University Press (OUP), 2008-11-29)
Isolation of salivary MUC7 with gel electrophoresis allowed analysis by LC-MS and LC-MS(2) of released O-linked oligosaccharides and a thorough description of the glycosylation of this molecule, where high-molecular-weight ...
<i>phip</i> - a novel candidate breast cancer susceptibility locus on 6q14.1
(Impact Journals, LLC, 2017-11-28)
Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent ...
Towards precision medicine: discovering novel gynecological cancer biomarkers and pathways using linked data
(Springer Nature, 2017-09-19)
Background: Next Generation Sequencing (NGS) is playing a key role in therapeutic decision making for the cancer prognosis and treatment. The NGS technologies are producing a massive amount of sequencing datasets. Often, ...