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A mixed methods study to assess the feasibility of a randomised controlled trial of invasive urodynamic testing versus clinical assessment and non-invasive tests prior to surgery for stress urinary incontinence in women: the investigate-i study
(Springer Nature, 2015-09-08)
Background: The position of invasive urodynamic testing (IUT) in diagnostic pathways for urinary incontinence is unclear, and systematic reviews have called for further trials evaluating clinical utility. The objective of ...
Comparison of 6q25 breast cancer hits from asian and european genome wide association studies in the breast cancer association consortium (bcac)
(Public Library of Science (PLoS), 2012-08-07)
The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting ...
Investigate-i (invasive evaluation before surgical treatment of incontinence gives added therapeutic effect?): a mixed-methods study to assess the feasibility of a future randomised controlled trial of invasive urodynamic testing prior to surgery for stress urinary incontinence in women
(National Institute for Health Research, 2015-02-01)
Urinary incontinence (UI), while rarely life-threatening, may seriously influence the physical, psychological and social well-being of affected individuals.(1-4) The impact on the families and carers may be profound and ...
Inflammation in aki: current understanding, key questions, and knowledge gaps
(American Society of Nephrology (ASN), 2015-11-11)
Inflammation is a complex biologic response that is essential for eliminating microbial pathogens and repairing tissue after injury. AKI associates with intrarenal and systemic inflammation; thus, improved understanding ...
Overweight in school-aged children and its relationship with demographic and lifestyle factors: results from the who-collaborative health behaviour in school-aged children (hbsc) study
(Springer Nature, 2009-07-21)
Objectives: To examine overweight prevalence and its association with demographic and lifestyle factors in 11-15 year olds in the HBSC 2005-2006 survey.
Methods: Self-reports of height, weight, eating patterns, physical ...
A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains
(Wiley-Blackwell, 2017-08-29)
This large multi-center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi-modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients ...
Do mothers accurately identify their child’s overweight/obesity status during early childhood? evidence from a nationally representative cohort study
(Springer Nature, 2018-06-19)
Background: Maternal recognition of overweight/obesity during early childhood is a key determinant in achieving healthy weight status in children. The aim of this study is to 1) investigate maternal perceptions of their ...
Common germline polymorphisms associated with breast cancer-specific survival
(Springer Nature, 2015-04-22)
Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was ...
Comparison of viral env proteins from acute and chronic infections with subtype c human immunodeficiency virus type 1 identifies differences in glycosylation and ccr5 utilization and suggests a new strategy for immunogen design
(American Society for Microbiology, 2013-04-24)
Understanding human immunodeficiency virus type 1 (HIV-1) transmission is central to developing effective prevention strategies, including a vaccine. We compared phenotypic and genetic variation in HIV-1 env genes from ...