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Differential response of mouse thymic epithelial cell types to ionizing radiation-induced dna damage
(Frontiers Media SA, 2017-04-13)
Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic ...
Large-scale cognitive gwas meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets
(Elsevier BV, 2017-11-01)
Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g''), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified ...
Inflammation-associated dna methylation patterns in epithelium of ulcerative colitis
(Informa UK Limited, 2017-05-30)
Aberrant DNA methylation patterns have been reported in inflamed tissues and may play a role in disease. We studied DNA methylation and gene expression profiles of purified intestinal epithelial cells from ulcerative colitis ...
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
(Springer Nature, 2017-03-30)
Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ...
a novel mechanism, linked to cell density, largely controls cell division in synechocystis
(American Society of Plant Biologists (ASPB), 2017-06-23)
Many studies have investigated the various genetic and environmental factors regulating cyanobacterial growth. Here, we investigated the growth and metabolism of Synechocystis sp. PCC 6803 under different nitrogen sources, ...
Clinical use of the oncotype dx genomic test to guide treatment decisions for patients with invasive breast cancer
(Dove Medical Press Ltd., 2017-05-01)
Implementation of the Oncotype DX assay has led to a change in the manner in which chemotherapy is utilized in patients with early stage, estrogen receptor (ER)-positive, node-negative breast cancer; ensuring that patients ...
Elicitation of resistance and associated defense responses in trichoderma hamatum induced protection against pearl millet downy mildew pathogen
(Springer Nature, 2017-03-21)
Endophytic Trichoderma hamatum UoM 13 isolated from pearl millet roots was evaluated for its efficiency to suppress downy mildew disease. Under laboratory conditions, T. hamatum seed treatment significantly enhanced pearl ...
estrogen deficiency attenuates fluid flow–induced [ca 2+ ] i oscillations and mechanoresponsiveness of mlo-y4 osteocytes
(FASEB, 2017-03-31)
It has been proposed that estrogen regulates the mechanosensitivity of osteocytes; however, the effects of estrogen deficiency that arises during postmenopausal osteoporosis on mechanical stimulation induced calcium signaling ...
Regulation of the unfolded protein response by noncoding rna
(American Physiological Society, 2017-09-01)
Cells are exposed to various intrinsic and extrinsic stresses in both physiological and pathological conditions. To adapt to those conditions, cells have evolved various mechanisms to cope with the disturbances in protein ...
An atr‐dependent function for the ddx19 rna helicase in nuclear r‐loop metabolism
(EMBO, 2017-03-17)
Coordination between transcription and replication is crucial in the maintenance of genome integrity. Disturbance of these processes leads to accumulation of aberrant DNA: RNA hybrids (R-loops) that, if unresolved, generate ...