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Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial
Anand, Sonia S; Bosch, Jackie; Eikelboom, John W; Connolly, Stuart J; Diaz, Rafael; Widimsky, Peter; Aboyans, Victor; Alings, Marco; Kakkar, Ajay K; Keltai, Katalin; Maggioni, Aldo P; Lewis, Basil S; Störk, Stefan; Zhu, Jun; Lopez-Jaramillo, Patricio; O'Donnell, Martin; Commerford, Patrick J; Vinereanu, Dragos; Pogosova, Nana; Ryden, Lars; Fox, Keith A A; Bhatt, Deepak L; Misselwitz, Frank; Varigos, John D; Vanassche, Thomas; Avezum, Alvaro A; Chen, Edmond; Branch, Kelley; Leong, Darryl P; Bangdiwala, Shrikant I; Hart, Robert G; Yusuf, Salim; SALA, JORGELINA; CARTASEGNA, LUIS; VICO, MARISA; HOMINAL, MIGUEL ANGEL; HASBANI, EDUARDO; CACCAVO, ALBERTO; ZAIDMAN, CESAR; VOGEL, DANIEL; HRABAR, ADRIAN; SCHYGIEL, PABLO OMAR; CUNEO, CARLOS; LUQUEZ, HUGO; MACKINNON, IGNACIO J.; AHUAD GUERRERO, RODOLFO ANDRES; COSTABEL, JUAN PABLO; BARTOLACCI, INES PALMIRA; MONTANA, OSCAR; BARBIERI, MARIA; GOMEZ VILAMAJO, OSCAR; GARCIA DURAN, RUBEN OMAR; SCHIAVI, LILIA BEATRIZ; GARRIDO, MARCELO; INGARAMO, ADRIAN; BORDONAVA, ANSELMO PAULINO; PELAGAGGE, MARIA JOSE; NOVARETTO, LEONARDO; ALBISU DI GENNERO, JUAN PABLO; IBANEZ SAGGIA, LUZ MARIA; ALVAREZ, MOIRA; VITA, NESTOR ALEJANDRO; MACIN, STELLA MARIS; DRAN, RICARDO DARIO; CARDONA, MARCELO; GUZMAN, LUIS; SARJANOVICH, RODOLFO JUAN; CUADRADO, JESUS; NANI, SEBASTIAN; LITVAK BRUNO, MARCOS RAUL; CHACON, CAROLINA; MAFFEI, LAURA ELENA; GRINFELD, DIEGO; VENSENTINI, NATALIA; MAJUL, CLAUDIO RODOLFO; LUCIARDI, HECTOR LUCAS; GONZALEZ COLASO, PATRICIA DEL CARMEN; FERRE PACORA, FREDY ANTONI; VAN DEN HEUVEL, PAUL; VERHAMME, PETER; ECTOR, BAVO; DEBONNAIRE, PHILIPPE; VAN DE BORNE, PHILIPPE; LEROY, JEAN; SCHROE, HERMAN; VRANCKX, PASCAL; ELEGEERT, IVAN; HOFFER, ETIENNE; DUJARDIN, KARL; INDIO DO BRASIL, CLARISSE; PRECOMA, DALTON; ABRANTES, JOSE ANTONIO; MANENTI, EULER; REIS, GILMAR; SARAIVA, JOSE; MAIA, LILIA; HERNANDES, MAURO; ROSSI, PAULO; ROSSI DOS SANTOS, FABIO; ZIMMERMANN, SERGIO LUIZ; RECH, RAFAEL; ABIB JR, EDUARDO; LEAES, PAULO; BOTELHO, ROBERTO; DUTRA, OSCAR; SOUZA, WEIMAR; BRAILE, MARIA; IZUKAWA, NILO; NICOLAU, JOSE CARLOS; TANAJURA, LUIZ FERNANDO; SERRANO JUNIOR, CARLOS VICENTE; MINELLI, CESAR; NASI, LUIZ ANTONIO; OLIVEIRA, LIVIA; DE CARVALHO CANTARELLI, MARCELO JOSE; TYTUS, RICHARD; PANDEY, SHEKHAR; LONN, EVA; CHA, JAMES; VIZEL, SAUL; BABAPULLE, MOHAN; LAMY, ANDRE; SAUNDERS, KEVIN; BERLINGIERI, JOSEPH; KIAII, BOB; BHARGAVA, RAKESH; MEHTA, PRAVINSAGAR; HILL, LAURIE; FELL, DAVID; LAM, ANDY; AL-QOOFI, FAISAL; BROWN, CRAIG; PETRELLA, ROBERT; RICCI, JOSEPH A; GLANZ, ANTHONY; NOISEUX, NICOLAS; BAINEY, KEVIN; MERALI, FATIMA; HEFFERNAN, MICHAEL; DELLA SIEGA, ANTHONY; DAGENAIS, GILLES R; DAGENAIS, FRANCOIS; BRULOTTE, STEEVE; NGUYEN, MICHEL; HARTLEIB, MICHAEL; GUZMAN, RANDOLPH; BOURGEOIS, RONALD; RUPKA, DENNIS; KHAYKIN, YAARIV; GOSSELIN, GILBERT; HUYNH, THAO; PILON, CLAUDE; CAMPEAU, JEAN; PICHETTE, FRANCIS; DIAZ, ARIEL; JOHNSTON, JAMES; SHUKLE, PRAVIN; HIRSCH, GREGORY; RHEAULT, PAUL; CZARNECKI, WLODZIMIERZ; ROY, ANNIE; NAWAZ, SHAH; FREMES, STEPHEN; SHUKLA, DINKAR; JANO, GABRIEL; COBOS, JORGE LEONARDO; CORBALAN, RAMON; MEDINA, MARCELO; NAHUELPAN, LEONARDO; RAFFO, CARLOS; PEREZ, LUIS; POTTHOFF, SERGIO; STOCKINS, BENJAMIN; SEPULVEDA, PABLO; PINCETTI, CHRISTIAN; VEJAR, MARGARITA; TIAN, HONGYAN; WU, XUESI; KE, YUANNAN; JIA, KAIYING; YIN, PENGFEI; WANG, ZHAOHUI; YU, LITIAN; WU, SHULIN; WU, ZONGQUI; LIU, SHAO WEN; BAI, XIAO JUAN; ZHENG, YANG; YANG, PING; YANG, YUN MEI; ZHANG, JIWEI; GE, JUNBO; CHEN, XIAO PING; LI, JUNXIA; HU, TAO HONG; ZHANG, RUIYAN; ZHENG, ZHE; CHEN, XIN; TAO, LIANG; LI, JIANPING; HUANG, WEIJIAN; FU, GUOSHENG; LI, CHUNJIAN; DONG, YUGANG; WANG, CHUNSHENG; ZHOU, XINMIN; KONG, YE; SOTOMAYOR, ARISTIDES; ACCINI MENDOZA, JOSE LUIS; CASTILLO, HENRY; URINA, MIGUEL; AROCA, GUSTAVO; PEREZ, MARITZA; MOLINA DE SALAZAR, DORA INES; SANCHEZ VALLEJO, GREGORIO; MANZUR J, FERNANDO; GARCIA, HENRY; GARCIA, LUIS HERNANDO; ARCOS, EDGAR; GOMEZ, JUAN; CUERVO MILLAN, FRANCISCO; TRUJILLO DADA, FREDY ALBERTO; VESGA, BORIS; MORENO SILGADO, GUSTAVO ADOLFO; ZIDKOVA, EVA; LUBANDA, JEAN-CLAUDE; KALETOVA, MARKETA; KRYZA, RADIM; MARCINEK, GABRIEL; RICHTER, MAREK; SPINAR, JINDRICH; MATUSKA, JIRI; TESAK, MARTIN; MOTOVSKA, ZUZANA; BRANNY, MARIAN; MALY, JIRI; MALY, MARTIN; WIENDL, MARTIN; FOLTYNOVA CAISOVA, LENKA; SLABY, JOSEF; VOJTISEK, PETR; PIRK, JAN; SPINAROVA, LENKA; BENESOVA, MIROSLAVA; CANADYOVA, JULIA; HOMZA, MIROSLAV; FLORIAN, JINDRICH; POLASEK, ROSTISLAV; COUFAL, ZDENEK; SKALNIKOVA, VLADIMIRA; BRAT, RADIM; BRTKO, MIROSLAV; JANSKY, PETR; LINDNER, JAROSLAV; MARCIAN, PAVEL; STRAKA, ZBYNEK; TRETINA, MARTIN; DUARTE, YAN CARLOS; POW CHON LONG, FREDDY; SANCHEZ, MAYRA; LOPEZ, JOSE; PERUGACHI, CARMITA; MARMOL, RICARDO; TRUJILLO, FREDDY; TERAN, PABLO; TUOMILEHTO, JAAKKO; TUOMILEHTO, HENRI; TUOMINEN, MARJA-LEENA; TUOMILEHTO, HENRI; KANTOLA, ILKKA; STEG, GABRIEL; ABOYANS, VICTOR; LECLERCQ, FLORENCE; FERRARI, EMILE; BOCCARA, FRANCK; MESSAS, EMMANUEL; MISMETTI, PATRICK; SEVESTRE, MARIE ANTOINETTE; CAYLA, GUILLAUME; MOTREFF, PASCAL; STOERK, STEFAN; DUENGEN, HANS-DIRK; STELLBRINK, CHRISTOPH; GUEROCAK, OSMAN; KADEL, CHRISTOPH; BRAUN-DULLAEUS, RUEDIGER; JESERICH, MICHAEL; OPITZ, CHRISTIAN; VOEHRINGER, HANS-FRIEDRICH; APPEL, KARL-FRIEDRICH; WINKELMANN, BERNHARD; DORSEL, THOMAS; NIKOL, SIGRID; DARIUS, HARALD; RANFT, JURGEN; SCHELLONG, SEBASTIAN; JUNGMAIR, WOLFGANG; DAVIERWALA, PIROZE; VORPAHL, MARC; BAJNOK, LASZLO; LASZLO, ZOLTAN; NOORI, EBRAHIM; VERESS, GABOR; VERTES, ANDRAS; ZSARY, ANDRAS; KIS, ERNO; KORANYI, LASZLO; BAKAI, JUDIT; BODA, ZOLTAN; POOR, FERENC; JARAI, ZOLTAN; KEMENY, VENDEL; BARTON, JOHN; MCADAM, BRENDAN; MURPHY, ANDREW; CREAN, PETER; MAHON, NIALL; CURTIN, RONAN; MACNEILL, BRIAIN; DINNEEN, SEAN; HALABI, MAJDI; ZIMLICHMAN, REUVEN; ZELTSER, DAVID; TURGEMAN, YOAV; KLAINMAN, ELIEZER; LEWIS, BASIL; KATZ, AMOS; ATAR, SHAUL; ZIMLICHMAN, REUVEN; NIKOLSKY, EUGENIA; BOSI, STEFANO; NALDI, MONICA; FAGGIANO, POMPILIO; ROBBA, DEBORA; MOS, LUCIO; SINAGRA, GIANFRANCO; COSMI, FRANCO; OLTRONA VISCONTI, LUIGI; CARMINE, DE MATTEIS; DI PASQUALE, GIUSEPPE; DI BIASE, MATTEO; MANDORLA, SARA; BERNARDINANGELI, MARINO; PICCINNI, GIOVANNI CARLO; GULIZIA, MICHELE MASSIMO; GALVANI, MARCELLO; VENTURI, FLAVIO; MOROCUTTI, GIORGIO; BALDIN, MARIA GRAZIA; OLIVIERI, CARLO; PERNA, GIAN PIERO; CIRRINCIONE, VINCENZO; KANNO, TAKAYASU; DAIDA, HIROYUKI; OZAKI, YUKIO; MIYAMOTO, NAOMASA; HIGASHIUE, SHINICHI; DOMAE, HIROSHI; HOSOKAWA, SHINOBU; KOBAYASHI, HIROO; KURAMOCHI, TAKEHIKO; FUJII, KENSHI; MIZUTOMI, KAZUAKI; SAKU, KEIJIRO; KIMURA, KAZUO; HIGUCHI, YOSHIHARU; ABE, MITSUNORI; OKUDA, HARUHITO; NODA, TOSHIYUKI; MITA, TERUAKI; HIRAYAMA, ATSUSHI; ONAKA, HARUHIKO; INOKO, MORIAKI; HIROKAMI, MITSUGU; OKUBO, MUNENORI; AKATSUKA, YUTAKA; IMAMAKI, MIZUHO; KAMIYA, HARUO; MANITA, MAMORU; HIMI, TOSHIHARU; UENO, HIDEKI; HISAMATSU, YUJI; AKO, JUNYA; NISHINO, YASUHIRO; KAWAKAMI, HIDEO; YAMADA, YUTAKA; KORETSUNE, YUKIHIRO; YAMADA, TAKAHISA; YOSHIDA, TETSURO; SHIMOMURA, HIDEKI; KINOSHITA, NORIYUKI; TAKAHASHI, AKIHIKO; YUSOFF, KHALID; WAN AHMAD, WAN AZMAN; ABU HASSAN, MUHAMMAD RADZI; KASIM, SAZZLI; ABDUL RAHIM, AIZAI AZAN; MOHD ZAMRIN, DIMON; MACHIDA, MASAHARU; HIGASHINO, YORIHIKO; UTSU, NORIAKI; NAKANO, AKIHIKO; NAKAMURA, SHIGERU; HASHIMOTO, TETSUO; ANDO, KENJI; SAKAMOTO, TOMOHIRO; PRINS, F.J.; LOK, DIRK; MILHOUS, JOHANNES GERT-JAN; VIERGEVER, ERIC; WILLEMS, FRANK; SWART, HENK; ALINGS, MARCO; BREEDVELD, ROB; DE VRIES, KEES-JAN; VAN DER BORGH, ROGER; OEI, FANNY; ZOET-NUGTEREN, STIENEKE; KRAGTEN, HANS; HERRMAN, JEAN PAUL; VAN BERGEN, PAUL; GOSSELINK, MARCEL; HOEKSTRA, EDUARD; ZEGERS, ERWIN; RONNER, EELKO; DEN HARTOG, FRANK; BARTELS, GERARD; NIEROP, PETER; VAN DER ZWAAN, COEN; VAN ECK, JACOB; VAN GORSELEN, EDWIN; GROENEMEIJER, BJORN; HOOGSLAG, PIETER; DE GROOT, MARC ROBERT; LOYOLA, ALDRIN; SULIT, DENNIS JOSE; REY, NANNETTE; ABOLA, MARIA TERESA; MORALES, DANTE; PALOMARES, ELLEN; ABAT, MARC EVANS; ROGELIO, GREGORIO; CHUA, PHILIP; DEL PILAR, JOSE CARLO; ALCARAZ, JOHN DENNIS; EBO, GERALDINE; TIRADOR, LOUIE; CRUZ, JOSEFINA; ANONUEVO, JOHN; PITARGUE, ARTHUR; JANION, MARIANNA; GUZIK, TOMASZ; GAJOS, GRZEGORZ; ZABOWKA, MACIEJ; RYNKIEWICZ, ANDRZEJ; BRONCEL, MARLENA; SZUBA, ANDRZEJ; CZARNECKA, DANUTA; MAGA, PAWEL; STRAZHESKO, IRINA; VASYUK, YURY; SIZOVA, ZHANNA; POZDNYAKOV, YURY; BARBARASH, OLGA; VOEVODA, MIKHAIL; POPONINA, TATIANA; REPIN, ALEXEY; OSIPOVA, IRINA; EFREMUSHKINA, ANNA; NOVIKOVA, NINA; AVERKOV, OLEG; ZATEYSHCHIKOV, DMITRY; VERTKIN, ARKADIY; AUSHEVA, AZA; COMMERFORD, PATRICK; SEEDAT, SAADIYA; VAN ZYL, LOUIS; ENGELBRECHT, JAN; MAKOTOKO, ELLEN MAKONLI; PRETORIUS, CATHARINA ELIZABETH; MOHAMED, ZAID; HORAK, ADRIAN; MABIN, THOMAS; KLUG, ERIC; BAE, JANG-HO; KIM, CHEOLHO; KIM, CHONG-JIN; KIM, DONG-SOO; KIM, YONG JIN; JOO, SEUNGJAE; HA, JONG-WON; PARK, CHUL SOO; KIM, JANG YOUNG; KIM, YOUNG-KWON; JARNERT, CHRISTINA; MOOE, THOMAS; DELLBORG, MIKAEL; TORSTENSSON, INGEMAR; ALBERTSSON, PER; JOHANSSON, LARS; AL-KHALILI, FARIS; ALMROTH, HENRIK; ANDERSSON, TOMMY; PANTEV, EMIL; TENGMARK, BENGT-OLOV; LIU, BO; RASMANIS, GUNDARS; WAHLGREN, CARL-MAGNUS; MOCCETTI, TIZIANO; PARKHOMENKO, ALEXANDER; TSELUYKO, VIRA; VOLKOV, VOLODYMYR; KOVAL, OLENA; KONONENKO, LYUDMYLA; PROKHOROV, OLEKSANDR; VDOVYCHENKO, VALERIY; BAZYLEVYCH, ANDRIY; RUDENKO, LEONID; VIZIR, VADYM; KARPENKO, OLEKSANDR; MALYNOVSKY, YAROSLAV; KOVAL, VALENTYNA; STOROZHUK, BORYS; COTTON, JAMES; VENKATARAMAN, ASOK; MORIARTY, ANDREW; CONNOLLY, DEREK; DAVEY, PATRICK; SENIOR, ROXY; BIRDI, INDERPAUL; CALVERT, JOHN; DONNELLY, PATRICK; TREVELYAN, JASPER; CARTER, JUSTIN; PEACE, AARON; AUSTIN, DAVID; KUKREJA, NEVILLE; HILTON, THOMAS; SRIVASTAVA, SUNNY; WALSH, RONALD; FIELDS, RONALD; HAKAS, JOSEPH; PORTNAY, EDWARD; GOGIA, HARINDER; SALACATA, ABRAHAM; HUNTER, JOHN J.; BACHARACH, J MICHAEL; SHAMMAS, NICOLAS; SURESH, DAMODHAR; SCHNEIDER, RICKY; GURBEL, PAUL; BANERJEE, SUBHASH; GRENA, PAUL; BEDWELL, NOEL; SLOAN, STEPHEN; LUPOVITCH, STEVEN; SONI, ANAND; GIBSON, KATHLEEN; SANGRIGOLI, RENEE; MEHTA, RAJENDRA; I-HSUAN TSAI, PETER; GILLESPIE, EVE; DEMPSEY, STEPHEN; HAMROFF, GLENN; BLACK, ROBERT; LADER, ELLIS; KOSTIS, JOHN B.; BITTNER, VERA; MCGUINN, WILLIAM; BRANCH, KELLEY; MALHOTRA, VINAY; MICHAELSON, STEPHEN; VACANTE, MICHAEL; MCCORMICK, MATTHEW; ARIMIE, RALUCA; CAMP, ALAN; DAGHER, GEORGE; KOSHY, N. MATHEW; THEW, STEPHEN; COSTELLO, FREDERICK; HEIMAN, MARK; CHILTON, ROBERT; MORAN, MICHAEL; ADLER, FREDRIC; COMEROTA, ANTHONY; SEIWERT, ANDREW; FRENCH, WILLIAM; SEROTA, HARVEY; HARRISON, ROBERT; BAKAEEN, FAISAL; OMER, SHUAB; CHANDRA, LOKESH; WHELAN, ALAN; BOYLE, ANDREW; ROBERTS-THOMSON, PHILIP; ROGERS, JAMES; CARROLL, PATRICK; COLQUHOUN, DAVID; SHAW, JAMES; BLOMBERY, PETER; AMERENA, JOHN; HII, CHRIS; ROYSE, ALISTAIR; SINGH, BHUWAN; SELVANAYAGAM, JOSEPH; JANSEN, SHIRLEY; LO, WINGCHI; HAMMETT, CHRISTOPHER; POULTER, ROHAN; NARASIMHAN, SESHASAYEE; WIGGERS, HENRIK; NIELSEN, HENRIK; GISLASON, GUNNAR; KOBER, LARS; HOULIND, KIM; BOENELYKKE SOERENSEN, VIBEKE; DIXEN, ULRIK; REFSGAARD, JENS; ZEUTHEN, ELISABETH; SOEGAARD, PETER; HRANAI, MARIAN; GASPAR, LUDOVIT; PELLA, DANIEL; HATALOVA, KATARINA; DROZDAKOVA, ERIKA; COMAN, IOAN; DIMULESCU, DOINA; VINEREANU, DRAGOS; CINTEZA, MIRCEA; SINESCU, CRINA; ARSENESCU, CATALINA; BENEDEK, IMRE; BOBESCU, ELENA; DOBREANU, DAN; GAITA, DAN; IANCU, ADRIAN; ILIESIU, ADRIANA; LIGHEZAN, DANIEL; PETRESCU, LUCIAN; PIRVU, OCTAVIAN; TEODORESCU, IULIA; TESLOIANU, DAN; VINTILA, MARIUS MARCIAN; CHIONCEL, OVIDIU (Elsevier BV, 2017-11-01)
Background Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.
Methods This was a multicentre, ...