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Integrating the genomic architecture of human nucleolar organizer regions with the biophysical properties of nucleoli
Nucleoli are the sites of ribosome biogenesis and the largest membraneless subnuclear structures. They are intimately linked with growth and proliferation control and function as sensors of cellular stress. Nucleoli form ...
Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division
(Informa UK Limited, 2014-08-18)
The cell nucleus is functionally compartmentalized into numerous membraneless and dynamic, yet defined, bodies. The cell cycle inheritance of these nuclear bodies (NBs) is poorly understood at the molecular level. In higher ...
Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division
(Cold Spring Harbor Laboratory, 2014-01-21)
Human cell nuclei are functionally organized into structurally stable yet dynamic bodies whose cell cycle inheritance is poorly understood. Here, we investigate the biogenesis and propagation of nucleoli, sites of ribosome ...