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Targeting selectins and their ligands in cancer
(Frontiers Media SA, 2016-04-18)
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune ...
E-selectin ligands recognised by heca452 induce drug resistance in myeloma, which is overcome by the e-selectin antagonist, gmi-1271
(Springer Nature, 2017-04-25)
Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ST3Gal-6, an enzyme ...